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Titolo:
PET mapping of extrastriatal D2-like dopamine receptors in the human brainusing an anatomic standardization technique and [C-11]FLB 457
Autore:
Okubo, Y; Olsson, H; Ito, H; Lofti, M; Suhara, T; Halldin, C; Farde, L;
Indirizzi:
Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Sect, S-17176 Stockholm, Sweden Tokyo Med & Dent Univ, Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 10, anno: 1999,
pagine: 666 - 674
SICI:
1053-8119(199912)10:6<666:PMOEDD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; I-125 EPIDEPRIDE; BASAL GANGLIA; D-2-DOPAMINE RECEPTORS; TEMPORAL-LOBE; BINDING; LOCALIZATION; CLOZAPINE; CORTEX;
Keywords:
D2 dopamine receptors; [C-11]FLB 451; positron emission tomography; human brain; anatomic standardization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Okubo, Y Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 7176 Stockholm, Sweden
Citazione:
Y. Okubo et al., "PET mapping of extrastriatal D2-like dopamine receptors in the human brainusing an anatomic standardization technique and [C-11]FLB 457", NEUROIMAGE, 10(6), 1999, pp. 666-674

Abstract

The Computerized Brain Atlas (CBA) transforms PET images of individual subjects into a standard brain anatomy. We have previously applied this to PETimages with [C-11]raclopride and confirmed that the D2 dopamine receptors in the striatum can be evaluated accurately with a standard brain anatomy. There is growing evidence that extrastriatal D2 receptors, in spite of their low density, have pathophysiological significance for schizophrenia. We used the CBA to explore the extrastriatal distribution of D2 receptors in 13healthy subjects using [C-11]FLB 457, a substituted benzamide with very high affinity for D2 and D3 receptors. There was good agreement between the specific binding ratios from CBA quantification of standardized images and those from region-of-interest analyses of original images. The highest levels of binding mere observed in the putamen and caudate nucleus, followed by the globus pallidus and nucleus accumbens. Besides the basal ganglia, the hypothalamus and nucleus ruber also showed high levels of binding. Intermediate levels were found in the substantia Ingra, nucleus subthalami, amygdala, and thalamus. Interestingly, there was very heterogeneous binding among the thalamic nuclei. The anterior and mediodorsal nuclei showed relatively high binding. The cerebral cortices showed lower levels with significant regional differences. Binding was highest in the temporal cortex and hippocampus followed by the anterior cingulate gyrus, and the parietal and frontal cortices, but was lowest in the occipital cortex. The use of CBA for analysis of [C-11]FLB 457 binding makes it possible to build a normal database forthe extrastriatal D2 receptors in the living human brain. The heterogeneous distribution of D2 receptors provides an attractive opportunity for new research on the pathophysiology and drug treatment of schizophrenia. (C) 1999 Academic Press.

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Documento generato il 09/12/19 alle ore 03:41:30