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Titolo:
Clinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3,301 elderly people - The cardiovascular health study
Autore:
Longstreth, WT; Arnold, AM; Manolio, TA; Burke, GL; Bryan, N; Jungreis, CA; OLeary, D; Enright, PL; Fried, L;
Indirizzi:
Univ Washington, Dept Neurol & Epidemiol, Seattle, WA 98104 USA Univ Washington Seattle WA USA 98104 l & Epidemiol, Seattle, WA 98104 USA Univ Washington, Dept Biostat, Seattle, WA 98104 USA Univ Washington Seattle WA USA 98104 Dept Biostat, Seattle, WA 98104 USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Radiol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA Univ Pittsburgh, Med Ctr, Dept Radiol, Neuroradiol Div, Pittsburgh, PA USAUniv Pittsburgh Pittsburgh PA USA l, Neuroradiol Div, Pittsburgh, PA USA Univ Pittsburgh, Med Ctr, Dept Neurol Surg, Neuroradiol Div, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA g, Neuroradiol Div, Pittsburgh, PA USA Tufts Univ, New England Med Ctr, Dept Radiol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Med Ctr, Dept Radiol, Boston, MA 02111 USA Univ Arizona, Resp Sci Ctr, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 zona, Resp Sci Ctr, Tucson, AZ 85721 USA
Titolo Testata:
NEUROEPIDEMIOLOGY
fascicolo: 1, volume: 19, anno: 2000,
pagine: 30 - 42
SICI:
0251-5350(200001/02)19:1<30:CCOVAS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-REPLACEMENT THERAPY; MINI-MENTAL STATE; ALZHEIMERS-DISEASE; OLDER ADULTS; BRAIN; ABNORMALITIES; RISK; MR; HYPERTENSION; PERFORMANCE;
Keywords:
magnetic resonance imaging; aged; cognition; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Longstreth, WT Univ Washington, Harborview Med Ctr, Dept Neurol, Box 359775,325 9th Ave, Seattle, WA 98104 USA Univ Washington Box 359775,325 9th AveSeattle WA USA 98104
Citazione:
W.T. Longstreth et al., "Clinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3,301 elderly people - The cardiovascular health study", NEUROEPIDEM, 19(1), 2000, pp. 30-42

Abstract

To identify potential risk factors for and clinical manifestations of ventricular and sulcal enlargement on cranial magnetic resonance imaging (MRI),3,301 community-dwelling people 65 years or older without a history of stroke or transient ischemic attack underwent extensive standardized evaluations and MRI. In the multivariate model, increased age and white matter gradeon MRI were the dominant risk factors for ventricular and sulcal grade. For ventricular grade, other than race, for which non-Blacks had higher grades, models for men and women shared no other factors. For sulcal grades, models for men and women shared variables reflecting cigarette smoking and diabetes. Clinical features were correlated more strongly with ventricular than sulcal grade and more strongly for women than men. Significant age-adjusted correlations between ventricular grade and the Digit-Symbol SubstitutionTest were found for men and women. Prospective studies will be needed to extend findings of this cross-sectional analysis. Copyright (C) 2000 S. Karger AG. Basel.

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Documento generato il 01/12/20 alle ore 18:53:08