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Titolo:
Development of new adherent mutant from human myeloma-derived cell line: In vitro model of anaplastic transformation of myeloma
Autore:
Jung, KC; Park, CS; Sohn, HW; Kook, MC; Chung, DH; Choi, YK; Hyun, BH; Lee, IS; Bae, YM; Song, HG; Park, SH;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 thol, Seoul 110799, South Korea Seoul Natl Univ, Coll Med, Inst Allergy & Clin Immunol, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 unol, Seoul 110799, South Korea Chungbuk Natl Univ, Dept Pathol, Coll Med, Chongju 360763, South Korea Chungbuk Natl Univ Chongju South Korea 360763 hongju 360763, South Korea Korea Res Inst Biosch & Biotechnol, Lab Biol Resources, Taejon 305600, South Korea Korea Res Inst Biosch & Biotechnol Taejon South Korea 305600 South Korea
Titolo Testata:
MOLECULES AND CELLS
fascicolo: 6, volume: 9, anno: 1999,
pagine: 657 - 661
SICI:
1016-8478(199912)9:6<657:DONAMF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELLS; ADHESION MOLECULES; PERIPHERAL-BLOOD; MULTIPLE-MYELOMA; EXPRESSION;
Keywords:
anaplastic myeloma; IM-9/AD; in vitro model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Park, SH Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 110799, South KoreaSeoul Natl Univ Seoul South Korea 110799 ul 110799, South Korea
Citazione:
K.C. Jung et al., "Development of new adherent mutant from human myeloma-derived cell line: In vitro model of anaplastic transformation of myeloma", MOL CELLS, 9(6), 1999, pp. 657-661

Abstract

Anaplastic myeloma is a rare but distinct, biologically aggressive variantof myeloma which usually results from dedifferentiation or anaplastic transformation of the myeloma cells. The molecular mechanisms that determine the biologic behavior of anaplastic myeloma and effective treatment modalities have not been well known due to lack of in vitro models. In the present study, we have developed an anaplastically transformed mutant from a human myeloma-derived cell line. In the process of long-term culture of the myeloma-derived IM-9 cell line in low serum and nutrient conditions, an adherent mutant line was developed and named IM-9/AD. This mutant cell line displayed several characteristics resembling anaplastic myeloma such as: 1, large cells with large vesicular nucleus and prominent nucleolus, multinuclearity and high mitotic figures; 2, loss of leukocyte-associated antigens; and 3, higher tumorigenecity in scid mice than its parental cell line. This newly developed mutant cell line may serve as a readily available in vitro model to investigate the biology of anaplastic myeloma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 13:34:13