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Titolo:
Effects of dopamine and melatonin on the regulation of the PIT-1 isotype, placental growth hormone and lactogen gene expressions in the rat placenta
Autore:
Lee, CK; Kang, HS; Lee, BJ; Kang, HM; Choi, WS; Kang, SG;
Indirizzi:
Inje Univ, Dept Biol, Coll Nat Sci, Kimhae 621749, South Korea Inje Univ Kimhae South Korea 621749 Nat Sci, Kimhae 621749, South Korea Univ Ulsan, Dept Biol, Coll Nat Sci, Ulsan 680749, South Korea Univ UlsanUlsan South Korea 680749 l Nat Sci, Ulsan 680749, South Korea Chungju Univ, Dept Genet Engn, Chongju 360763, South Korea Chungju Univ Chongju South Korea 360763 ngn, Chongju 360763, South Korea Gyeongsang Natl Univ, Dept Anat, Coll Med, Chinju 660280, South Korea Gyeongsang Natl Univ Chinju South Korea 660280 hinju 660280, South Korea
Titolo Testata:
MOLECULES AND CELLS
fascicolo: 6, volume: 9, anno: 1999,
pagine: 646 - 651
SICI:
1016-8478(199912)9:6<646:EODAMO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENTARY DEOXYRIBONUCLEIC-ACID; CELL-SPECIFIC EXPRESSION; MOLECULAR-CLONING; PROLACTIN GENE; CHORIONIC SOMATOMAMMOTROPIN; TRANSCRIPTION FACTOR; RIBONUCLEIC-ACID; PREGNANT RAT; HUMAN RETINA; PROTEIN-A;
Keywords:
dopamine; dopamine receptor 2; melatonin; melatonin receptor 1a; Pit-1; placenta; placental lactogen; prolactin like protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kang, SG Inje Univ, Dept Biol, Coll Nat Sci, Kimhae 621749, South Korea Inje Univ Kimhae South Korea 621749 Kimhae 621749, South Korea
Citazione:
C.K. Lee et al., "Effects of dopamine and melatonin on the regulation of the PIT-1 isotype, placental growth hormone and lactogen gene expressions in the rat placenta", MOL CELLS, 9(6), 1999, pp. 646-651

Abstract

Rat placenta produces several members of the placental prolactin-growth hormone (PRL-GB), including placental lactogen (PL) and placental prolactin like protein (PLP), during pregnancy, It is important to study placental local regulators that control the expression of PRL-GH genes, We have previously reported that dopamine (DA) can regulate Pit-1 and PL-II gene expressions. In this study we aimed to investigate the local expression of melatonin receptor 1a (MeI1a) and the effects of DA and melatonin on the expressions of PL-Iv, PL-II, PLP-C genes and Pit-1 gene that are involved in the expression of PRL-GH genes in the rat pituitary and placenta. According to the Northern blot analysis, DA receptor 2 (D-2) was expressed in the rat placenta. We also report on the local expression of MeI1a in the rat placenta for the first time. Injected DA agonist, bromocriptine (in vivo) decreased PL-Iv, PLP-C and Pit-1 mRNA levels in the rat placenta, The melatonin agonist, chloromelatonin in culture media also decreased the levels of PL-IV, PL-II and PLP-C mRNA, However, melatonin does not affect the Pit-1 mRNA level, These data suggest that D-2 and MeI1a may control the expression of PRL-GH genes in the rat placenta and its response to the extracellular changes of DA and melatonin secreted from the maternal organ. However, Pit-1 may not be involved in the MeI1a induced inhibition of PRL-GH gene expressions in the rat placenta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:43:11