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Titolo:
Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and Ca-45(2+) uptake
Autore:
Plein, H; Berk, M; Eppel, S; Butkow, N;
Indirizzi:
Univ Witwatersrand, Dept Psychiat, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa Univ Witwatersrand, Dept Expt & Clin Pharmacol, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa
Titolo Testata:
LIFE SCIENCES
fascicolo: 5, volume: 66, anno: 2000,
pagine: 425 - 431
SICI:
0024-3205(2000)66:5<425:APCUIR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-MEMBRANE; CA-2+ INFLUX; DISORDERS; MODEL;
Keywords:
platelet; calcium; serotonin; manganese; Ca-45(2+) uptake; major depression; intracellular Mn2+ influx;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univ Witwatersrand, Dept Psychiat, Fac Hlth Sci, 7 York Rd, ZA-2193 Johannesburg, South Africa Univ Witwatersrand 7 York Rd Johannesburg South Africa ZA-2193 ca
Citazione:
H. Plein et al., "Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and Ca-45(2+) uptake", LIFE SCI, 66(5), 2000, pp. 425-431

Abstract

There is an augmented platelet intracellular calcium response to serotoninstimulation in major depression. The role that calcium influx has in this process is not known. The objective of this study was to determine plateletcalcium influx in response to serotonin by two methods, Mn2+ influx and Ca-45(2+) uptake, in order to observe if the uptake response to serotonin wasaugmented in major depression by comparing the response to normal controls. The use of the two methods of calcium influx showed that serotonin stimulates calcium uptake into platelets. Furthermore, patients with major depression have significantly augmented platelet calcium uptake in response to serotonin. The interesting finding was that calcium uptake into platelets is biphasic, occurring immediately and after five minutes. These results may support the two pool model for calcium oscillations within cells whereby extracellular calcium is needed for intracellular calcium release, and for replenishment of depleted stores once intracellular calcium is released.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 15:57:12