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Titolo:
The glomerular slit diaphragm is a modified adherens junction
Autore:
Reiser, J; Kriz, W; Kretzler, M; Mundel, P;
Indirizzi:
Albert Einstein Coll Med, Dept Med, Div Nephrol, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Nephrol, Bronx, NY 10461 USA Univ Heidelberg, Dept Anat & Cell Biol, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany Univ Munich, Dept Med, Munich, Germany Univ Munich Munich GermanyUniv Munich, Dept Med, Munich, Germany Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 uct Biol, Bronx, NY 10461 USA
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 1, volume: 11, anno: 2000,
pagine: 1 - 8
SICI:
1046-6673(200001)11:1<1:TGSDIA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-CELLS; PROTEIN ZO-1; BETA-CATENIN; RAT-KIDNEY; EXPRESSION; ADHESION; PERMEABILITY; ORGANIZATION; PODOCYTES; CADHERINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Mundel, P Albert Einstein Coll Med, Dept Med, Div Nephrol, 1300 Morris Pk Ave, Bronx, NY 10461 USA Albert Einstein Coll Med 1300 Morris Pk Ave Bronx NY USA 10461 A
Citazione:
J. Reiser et al., "The glomerular slit diaphragm is a modified adherens junction", J AM S NEPH, 11(1), 2000, pp. 1-8

Abstract

The glomerular slit diaphragm between podocyte foot processes shares typical morphologic features with an adherens junction. Differentiated cultured podocytes form cellular structures comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was coexpressed with P-cadherin as well as with alpha-, beta-, and gamma-catenin. In situ, P-cadherin was detected at the slit diaphragm in association with ZO-1 as shown by confocal microscopy and immunogold double labeling electron microscopy. P-cadherin expression in vivo and in vitro was confirmed by reverse transcription-PCR. These findings led to the concept that the slit diaphragm represents an adherens junction composed of P-cadherin, alpha-, beta-, and gamma-catenin, and ZO-1. In contrast to an adherens junction of a similar composition recently described in cultured fibroblasts, the slit diaphragm complex does not contain vinculin, which was found in nearby focal contacts. A P-cadherin-based adherens junction is well-suited to explain the zipper-like structure ofthe slit diaphragm. The present study should allow new avenues leading to the identification of additional slit diaphragm-associated proteins conferring specificity to this unique cell junction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:02:56