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Titolo:
Reversal of the postischaemic suppression of coronary function in perfusedguinea pig heart by ischaemic preconditioning
Autore:
Chlopicki, S; Lomnicka, M; Gryglewski, RJ;
Indirizzi:
Jagiellonian Univ, Coll Med, Dept Pharmacol, PL-31531 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31531 rmacol, PL-31531 Krakow, Poland
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 50, anno: 1999,
pagine: 605 - 615
SICI:
0867-5910(199912)50:4<605:ROTPSO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; ENDOTHELIAL DYSFUNCTION; RAT HEARTS; MYOCARDIAL PROTECTION; ANESTHETIZED DOGS; SKELETAL-MUSCLE; ADENOSINE; BRADYKININ; RECEPTOR; MULTIPLE;
Keywords:
ischaemic preconditioning; guinea pig heart; coronary circulation; endothelium; vascular smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chlopicki, S Jagiellonian Univ, Coll Med, Dept Pharmacol, Grzegorzecka 16,PL-31531 Krakow, Poland Jagiellonian Univ Grzegorzecka 16 Krakow Poland PL-31531 and
Citazione:
S. Chlopicki et al., "Reversal of the postischaemic suppression of coronary function in perfusedguinea pig heart by ischaemic preconditioning", J PHYSL PH, 50(4), 1999, pp. 605-615

Abstract

In the isolated guinea pig hearts suppression of endothelium-dependent (Acetylcholine, Substance P, postocclusive hyperaemia) and endothelium-independent (Sodium nitroprusside, PGE) responses after 30 min subglobal ischaemia(reduction of coronary flow to 5%) were analysed in hearts which were not preconditioned or preconditioned by various protocols. Preconditioning consisted of single 5 min ischaemia (IP5) or single 10 min ischaemia (IP10) or double 5 min ischaemia (IP5+5). Thirty minutes of ischaemia followed by reperfusion reduced both endothelium-dependent and endothelium-independent responses approximately by 30-50% and slightly suppressed basal coronary flow by 10%. IP5 and IP5+5 protected against postischaemic suppression of:responses to NaNP but not against postischaemic impairment of SP, ACh, and POH responses. The endothelium-dependent responses and postischaemic suppression of basal coronary flow were protected by IP10 only. In summary, in the isolated guinea pig heart the 30-min ischaemia impairs vasodilator responses toboth:endothelium-dependent and endothelium-independent agents. Ischaemic preconditioning protects both endothelial and smooth muscle cells function against this impairment, though endothelial cells require a more extensive preconditioning to put in motion protective mechanisms than smooth muscle cells do. independent mechanisms of IP in endothelial cells and in smooth muscle cells are suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:40:04