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Titolo:
Activity-related calcium dynamics in motoneurons of the nucleus hypoglossus from mouse
Autore:
Lips, MB; Keller, BU;
Indirizzi:
Univ Gottingen, Zentrum Physiol & Pathophysiol, D-37073 Gottingen, GermanyUniv Gottingen Gottingen Germany D-37073 iol, D-37073 Gottingen, Germany
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 6, volume: 82, anno: 1999,
pagine: 2936 - 2946
SICI:
0022-3077(199912)82:6<2936:ACDIMO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; PATCH-CLAMP RECORDINGS; STEM-SPINAL-CORD; RAT-BRAIN-STEM; NEONATAL RAT; RESPIRATORY NEURONS; PYRAMIDAL NEURONS; SYNAPTIC CURRENTS; FIRING BEHAVIOR; NERVOUS-SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Keller, BU Univ Gottingen, Zentrum Physiol & Pathophysiol, Humboldtallee 23, D-37073 Gottingen, Germany Univ Gottingen Humboldtallee 23 Gottingen Germany D-37073 many
Citazione:
M.B. Lips e B.U. Keller, "Activity-related calcium dynamics in motoneurons of the nucleus hypoglossus from mouse", J NEUROPHYS, 82(6), 1999, pp. 2936-2946

Abstract

A quantitative analysis of activity-related calcium dynamics was performedin motoneurons of the nucleus hypoglossus in the brain stem slice preparation from mouse by simultaneous patch-clamp and microfluorometric calcium measurements. Motoneurons were analyzed under in vitro conditions that kept them in a functionally intact state represented by rhythmic, inspiratory-related bursts of excitatory postsynaptic currents acid associated action potential discharges. Bursts of electrical activity were paralleled by somatic calcium transients resulting from calcium influx through voltage-activated calcium channels, where each action potential accounted for a calcium-mediated charge influx around 2 pC into the somatic compartment. Under in vivo conditions, rhythmic-respiratory activity in young mice occurred at frequencies up to 5 Hz, demonstrating the necessity for rapid calcium elevation andrecovery in respiratory-related neurons. The quantitative analysis of hypoglossal calcium homeostasis identified an average extrusion rate, but an exceptionally low endogenous calcium binding capacity as cellular parameters accounting for rapid calcium signaling. Our results suggest that dynamics of somatic calcium transients I) define an upper limit for the maximum frequency of respiratory-related burst discharges and 2) represent a potentiallydangerous determinant of intracellular calcium profiles during pathophysiological and/or excitotoxic conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:03:21