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Titolo:
CORONARY AVE MICRO STENTS - SERIAL QUANTITATIVE ANGIOGRAPHY AND HISTOLOGY IN A CANINE MODEL
Autore:
POMERANTSEV EV; KIM C; KERNOFF RS; OESTERLE SN; YEUNG A; FITZGERALD PJ; VIRMANI R; YOCK PG; STERTZER SH;
Indirizzi:
STANFORD UNIV,DIV CARDIOVASC MED,300 PASTEUR DR,CVRC 287 STANFORD CA 94305 STANFORD UNIV,DIV CARDIOVASC MED STANFORD CA 94305 ARMED FORCES INST PATHOL,DEPT CARDIAC MED WASHINGTON DC 20306
Titolo Testata:
Catheterization and cardiovascular diagnosis
fascicolo: 2, volume: 41, anno: 1997,
pagine: 213 - 224
SICI:
0098-6569(1997)41:2<213:CAMS-S>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Keywords:
CORONARY ARTERY DISEASE; AVE MICRO STENTS; CORONARY INTERVENTIONS; CORONARY LESION ANATOMY; PROCEDURAL RESULTS; COMPLICATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
E.V. Pomerantsev et al., "CORONARY AVE MICRO STENTS - SERIAL QUANTITATIVE ANGIOGRAPHY AND HISTOLOGY IN A CANINE MODEL", Catheterization and cardiovascular diagnosis, 41(2), 1997, pp. 213-224

Abstract

The AVE Micro Stent (AVE Inc., Santa Rosa, CA) is composed of helically welded 3 mm long, zigzag crowns with stent lengths from 6 to 39 mm and diameters from 2.5 to 4.5 mm. Quantitative coronary angiography and histologic analyses of acute and chronic implantation were obtained in 52 stented coronary segments of 18 dogs. Three hearts with 8 stented coronary segments were harvested after 24 hr, 3 hearts with 9 stented segments were harvested after 2 weeks, 6 hearts with 15 stented segments were harvested at 8 weeks, and 6 hearts with 20 stented segments were harvested at 24 weeks post-deployment. There were no procedural complications, deaths, or acute Vessel closures. The average lumen diameter of the stented segment was largest at 2 weeks (3.3 +/- 0.3 mm), The smallest average diameters were observed at 8 weeks after the stentdeployment (2.7 +/- 0.4, P < 0.05) with an increase again at 24 weeks(2.9 +/- 0.6). The pre-explant percent of stenosis was <30% in all animals, Histologically, a peak of inflammation was visible at 2 weeks; however, the extent of luminal narrowing reached its peak at 8 weeks and the lumen dimension increased somewhat at 24 weeks. The degree of intimal thickening remained relatively constant throughout the different time points (<200 mu m). Overall, these data suggest that constrictive remodeling within the stented segment occurs at 8 weeks in this animal model. The later increase of the stented segment dimensions as well as higher net gain at 24 weeks compared to 8 weeks after deployment suggests that this constriction is a transitory phenomenon. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:36:43