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Titolo:
Complexation of the non-steroidal anti-inflammatory drug Nabumetone with modified and unmodified cyclodextrins
Autore:
Valero, M; Costa, SMB; Ascenso, JR; Velazquez, MM; Rodriguez, LJ;
Indirizzi:
Inst Super Tecn, Ctr Quim Estrutural, P-1049001 Lisbon, Portugal Inst Super Tecn Lisbon Portugal P-1049001 al, P-1049001 Lisbon, Portugal Univ Salamanca, Fac Farm, Dept Quim Fis, E-37080 Salamanca, Spain Univ Salamanca Salamanca Spain E-37080 uim Fis, E-37080 Salamanca, Spain
Titolo Testata:
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
fascicolo: 4, volume: 35, anno: 1999,
pagine: 663 - 677
SICI:
1388-3127(199912)35:4<663:COTNAD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCLUSION COMPLEXES; BETA-CYCLODEXTRIN; ALPHA-CYCLODEXTRIN; NAPROXEN; COMPENSATION; BEHAVIOR;
Keywords:
Nabumetone; Naproxen; cyclodextrin; UV-absorption spectroscopy; fluorescence spectroscopy; thermodynamics; proton NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Costa, SMB Inst Super Tecn, Ctr Quim Estrutural, Complexo Interdisciplinar,Av RoviscoPais, P-1049001 Lisbon, Portugal Inst Super Tecn Complexo Interdisciplinar,Av Rovisco Pais Lisbon Portugal P-1049001
Citazione:
M. Valero et al., "Complexation of the non-steroidal anti-inflammatory drug Nabumetone with modified and unmodified cyclodextrins", J INCL P MA, 35(4), 1999, pp. 663-677

Abstract

The inclusion of the anti-inflammatory drug, Nabumetone, in alpha-, beta- and hydroxypropyl-beta-cyclodextrin (CDs) is studied using UV-VIS absorption and steady-state fluorescence emission. Binding constants and thermodynamic parameters of complex formation are determined by spectrofluorimetry. The inclusion phenomena of Nabumetone with the three cyclodextrins is compared with that of the well known similar anti-inflammatory drug Naproxen. In the case of Nabumetone pronounced differences are observed in the complexation process with each cyclodextrin whereas the respective Naproxen complexesare nearly identical. H-1-NMR experiments show that the inclusion process in Nabumetone can occur either through the substituents in the -2 (butanone) or -6 (methoxy) positions in the naphthalene ring.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:17:31