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Titolo:
Isolation and characterization of a human cDNA encoding a protein homologous to the 7.2-kDa protein (subunit X) of bovine ubiquinol-cytochrome C reductase
Autore:
Akashi, H; Han, HJ; Iizaka, M; Nakajima, Y; Furukawa, Y; Sugano, S; Imai, K; Nakamura, Y;
Indirizzi:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Mol Med,Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 b Mol Med,Minato Ku, Tokyo 1088639, Japan Univ Tokyo, Inst Med Sci, Dept Virol, Tokyo, Japan Univ Tokyo Tokyo Japan iv Tokyo, Inst Med Sci, Dept Virol, Tokyo, Japan Sapporo Med Univ, Dept Internal Med 1, Sapporo, Hokkaido, Japan Sapporo Med Univ Sapporo Hokkaido Japan Med 1, Sapporo, Hokkaido, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 45, anno: 2000,
pagine: 43 - 46
SICI:
1434-5161(2000)45:1<43:IACOAH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BC(1) COMPLEX; HEART-MITOCHONDRIA; BINDING PROTEIN; BC1 COMPLEX; BEEF-HEART; ASSIGNMENT; GENE; APOPTOSIS; SEQUENCE; GENOME;
Keywords:
ubiquinol-cytochrome C reductase; subunit X; cDNA library screening; mitochondria; respiratory chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, Y Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Mol Med,MinatoKu, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 ShirokanedaiTokyo Japan 1088639 8639, Japan
Citazione:
H. Akashi et al., "Isolation and characterization of a human cDNA encoding a protein homologous to the 7.2-kDa protein (subunit X) of bovine ubiquinol-cytochrome C reductase", J HUM GENET, 45(1), 2000, pp. 43-46

Abstract

Through large-scale sequencing of clones randomly selected from a library of human cDNAs, we have isolated a novel human gene termed hUQCR10. Its open reading frame encodes 63 amino acids that share 88.5% identity with the sequence of bovine ubiquinol-cytochrome C reductase 7.2-kDa protein (subunitX). A single 0.6-kb transcript was expressed in all human tissues examined, but was particularly abundant in heart and skeletal muscle, tissues that consume a large amount of oxygen. The gene product therefore may play a significant role in the cellular respiratory system. In support of this hypothesis, our immunohistochemical analysis revealed that the hUQCR10 protein islocated in mitochondria. A homology search using computer programs determined the chromosomal localization of the gene at 22q12.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:23:52