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Titolo:
Surmounting the multiple-minima problem in protein folding
Autore:
Scheraga, HA; Lee, J; Pillardy, J; Ye, YJ; Liwo, A; Ripoll, D;
Indirizzi:
Cornell Univ, Baker Lab Chem & Chem Biol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 b Chem & Chem Biol, Ithaca, NY 14853 USA Univ Gdansk, Fac Chem, PL-80952 Gdansk, Poland Univ Gdansk Gdansk PolandPL-80952 sk, Fac Chem, PL-80952 Gdansk, Poland Cornell Univ, Cornell Theory Ctr, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Cornell Theory Ctr, Ithaca, NY 14853 USA
Titolo Testata:
JOURNAL OF GLOBAL OPTIMIZATION
fascicolo: 3, volume: 15, anno: 1999,
pagine: 235 - 260
SICI:
0925-5001(199910)15:3<235:STMPIP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRIVEN MONTE-CARLO; PANCREATIC TRYPSIN-INHIBITOR; DIFFUSION EQUATION METHOD; INTRAMOLECULAR CONFORMATIONAL OPTIMIZATION; RESIDUE FORCE-FIELD; COILED-COIL CONFORMATION; MAGNETIC-RESONANCE DATA; MEMBRANE-BOUND PORTION; LENNARD-JONES ATOMS; AMINO-ACID-RESIDUES;
Keywords:
global optimization; multiple-minima problem; protein folding; structure prediction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Scheraga, HA Cornell Univ, Baker Lab Chem & Chem Biol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Biol, Ithaca, NY 14853 USA
Citazione:
H.A. Scheraga et al., "Surmounting the multiple-minima problem in protein folding", J GLOB OPT, 15(3), 1999, pp. 235-260

Abstract

Protein folding is a very difficult global optimization problem. Furthermore it is coupled with the difficult task of designing a reliable force field with which one has to search for the global minimum. A summary of a series of optimization methods developed and applied to various problems involving polypeptide chains is described in this paper. With recent developments,a computational treatment of the folding of globular proteins of up to 140residues is shown to be tractable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 22:46:46