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Titolo:
Development of afferent patterns in the inferior colliculus of the rat: Projection from the dorsal nucleus of the lateral lemniscus
Autore:
Gabriele, ML; Brunso-Bechtold, JK; Henkel, CK;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 3, volume: 416, anno: 2000,
pagine: 368 - 382
SICI:
0021-9967(20000117)416:3<368:DOAPIT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; OCULAR DOMINANCE COLUMNS; ANTEROVENTRAL COCHLEAR NUCLEUS; SUPERIOR OLIVARY COMPLEX; TONOTOPIC ORGANIZATION; DESCENDING PROJECTIONS; ASCENDING PROJECTIONS; POSTNATAL-DEVELOPMENT; GABAERGIC PROJECTION; EFFERENT PROJECTIONS;
Keywords:
auditory midbrain; commissure of Probst; carbocyanine dye; fibrodendritic laminae; layers; bands; patches;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Henkel, CK Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol & Anat, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 57 USA
Citazione:
M.L. Gabriele et al., "Development of afferent patterns in the inferior colliculus of the rat: Projection from the dorsal nucleus of the lateral lemniscus", J COMP NEUR, 416(3), 2000, pp. 368-382

Abstract

The inferior colliculus (IC) receives a variety of layered afferent projections. The purpose of the present study was to determine the development ofthe projection from the dorsal nucleus of the lateral lemniscus (DNLL) to the IC in rat prior to the onset of hearing (postnatal day 12/13). Lipophilic carbocyanine dye, DiI (1,1'-dioctodecyl-3,3,3',3'-tetramethylcyanine perchlorate), was used to trace the crossed inhibitory projection of DNLL in adevelopmental series of rat embryos and pups between ages embryonic day 15(E15) and postnatal day 12 (P12). Dye-coated pins were positioned in paraformaldehyde-fixed brains either unilaterally in DNLL (embryonic cases), or in the commissure of Probst where DNLL fibers cross the midline (postnatal cases). By E15, pioneer fibers have left DNLL and crossed the midline. A few fibers have nearly reached the contralateral IC by E19. At birth (E22 = P0), the projection has invaded ventromedial, high-frequency layers of the IC. The vast majority of DNLL axons parallel the presumptive IC layers by P4, and by P8 the projection has segregated into a pattern of bands (afferentdense) and interband (afferent: sparse) spaces that encompasses the entirefrequency axis of the IC. Adult-like patches, regions along afferent bandsthat exhibit the heaviest labeling, develop by P12. These results indicatethat some mature projection patterns are in place prior to the onset of hearing. Such findings suggest that evoked activity may not be required for the initial organization of patterned projections in the ascending auditory pathway. J. Comp. Neurol. 416:368-382, 2000. a (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:37:30