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Titolo:
Altered responsiveness to chemokines due to targeted disruption of SHIP
Autore:
Kim, CH; Hangoc, G; Cooper, S; Helgason, CD; Yew, S; Humphries, RK; Krystal, G; Broxmeyer, HE;
Indirizzi:
Indiana Univ, Sch Med, Dept Immunol Microbiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 robiol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Walther Oncol Ctr, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ol Ctr, Indianapolis, IN 46202 USA Walther Canc Inst, Indianapolis, IN 46208 USA Walther Canc Inst Indianapolis IN USA 46208 t, Indianapolis, IN 46208 USA British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada British Columbia Canc Agcy Vancouver BC Canada V5Z 1L3 BC V5Z 1L3, Canada Univ British Columbia, Dept Pathol, Vancouver, BC V5Z 1L3, Canada Univ British Columbia Vancouver BC Canada V5Z 1L3 ver, BC V5Z 1L3, Canada Univ British Columbia, Dept Lab Med, Vancouver, BC V5Z 1L3, Canada Univ British Columbia Vancouver BC Canada V5Z 1L3 ver, BC V5Z 1L3, Canada Univ British Columbia, Dept Med, Vancouver, BC V5Z 1L3, Canada Univ British Columbia Vancouver BC Canada V5Z 1L3 ver, BC V5Z 1L3, Canada
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 12, volume: 104, anno: 1999,
pagine: 1751 - 1759
SICI:
0021-9738(199912)104:12<1751:ARTCDT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INOSITOL PHOSPHATASE SHIP; MYELOID PROGENITOR CELLS; PROTEIN-3-BETA EBI1-LIGAND CHEMOKINE; POLYPHOSPHATE 5-PHOSPHATASE SHIP; AFFINITY IGE RECEPTOR; IN-VIVO; LYMPHOCYTE CHEMOATTRACTANT; HEMATOPOIETIC-CELLS; NEGATIVE REGULATION; T-LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Broxmeyer, HE Indiana Univ, Sch Med, Dept Immunol Microbiol, Bldg R4,Room 302,1044 W Walnut St, Indianapolis, IN 46202 USA Indiana Univ Bldg R4,Room 302,1044 W Walnut St Indianapolis IN USA 46202
Citazione:
C.H. Kim et al., "Altered responsiveness to chemokines due to targeted disruption of SHIP", J CLIN INV, 104(12), 1999, pp. 1751-1759

Abstract

SHIP has been implicated in negative signaling in a number of hematopoietic cell types and is postulated to downregulate phosphatidylinositol-3-kinase-(PI-3 K-) initiated events in diverse receptor signaling pathways. Because PI-SK is implicated in chemokine signaling, we investigated whether SHIP plays any role in cellular responses to chemokines. We found that a number of immature and mature hematopoietic cells from SHIP-deficient mice manifested enhanced directional migration (chemotaxis) in response to the chemokines stromal cell-derived factor-1 (SDF-1) and B-lymphocyte chemoattractant (BLC). SHIP-/- cells were also more active in calcium influx and actin polymerization in response to SDF-1. However, colony formation by SHIP-deficienthematopoietic progenitor cell (HPCs) was not inhibited by 13 myelosuppressive chemokines that normally inhibit proliferation of HPCs. These altered biologic activities of chemokines on SHIP-deficient cells are not caused by simple modulation of chemokine receptor expression in SHIP-deficient mice, implicating SHIP in the modulation of chemokine-induced signaling and downstream effects.

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Documento generato il 04/04/20 alle ore 15:33:41