Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DOPAMINE AND SODIUM APPETITE - ANTAGONISTS SUPPRESS SHAM DRINKING OF NACL SOLUTIONS IN THE RAT
Autore:
ROITMAN MF; SCHAFE GE; THIELE TE; BERNSTEIN IL;
Indirizzi:
UNIV WASHINGTON,DEPT PSYCHOL,BOX 351525 SEATTLE WA 98195 UNIV WASHINGTON,DEPT PSYCHOL SEATTLE WA 98195
Titolo Testata:
Behavioral neuroscience
fascicolo: 3, volume: 111, anno: 1997,
pagine: 606 - 611
SICI:
0735-7044(1997)111:3<606:DASA-A>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHORDA TYMPANI; RECEPTOR ANTAGONISTS; BRAIN; SYSTEMS; REWARD; NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Roitman et al., "DOPAMINE AND SODIUM APPETITE - ANTAGONISTS SUPPRESS SHAM DRINKING OF NACL SOLUTIONS IN THE RAT", Behavioral neuroscience, 111(3), 1997, pp. 606-611

Abstract

Sodium (Na) ingestion in rats depleted of Na is a strong, motivated behavior that is enhanced further when depleted rats are sham drinking. Dopamine plays a critical role in motivation, including reward associated with consumption of palatable tastes. The present studies assessed the role of dopamine in real and sham drinking of NaCl solutions after Na depletion with the diuretic furosemide (10 mg/kg). Dopamine (D2)receptor antagonists were evaluated (Haloperidol [0.1 mg/kg] and raclopride [0.2 mg/kg]), for their effects on sham and real drinking of 0.3 M NaCl. Sham drinking was markedly reduced by both antagonists whereas real drinking was unaffected. These effects did not appear to be due to malaise or suppression of motor behavior because drug-treated animals were able to increase ingestion substantially when offered less concentrated NaCl (0.1 M). These results suggest that the positive motivating properties of NaCl stimulation in depleted, sham-drinking rats are mediated by central D2 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:39:48