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Titolo:
Influence of chronic treatment with imipramine on mRNA levels in rat brain: Elevation of glyceraldehyde-3-phosphate dehydrogenase levels
Autore:
Tohda, M; Qi, Z; Watanabe, H;
Indirizzi:
Toyama Med & Pharmaceut Univ, Inst Wakan Yaku, Dept Pharmacol, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 4, volume: 81, anno: 1999,
pagine: 393 - 396
SICI:
0021-5198(199912)81:4<393:IOCTWI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; GENE; EXPRESSION; ACID;
Keywords:
differential display; antidepressant; glyceraldehyde-3-phosphate dehydrogenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Tohda, M Toyama Med & Pharmaceut Univ, Inst Wakan Yaku, Dept Pharmacol, 2630 Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
M. Tohda et al., "Influence of chronic treatment with imipramine on mRNA levels in rat brain: Elevation of glyceraldehyde-3-phosphate dehydrogenase levels", JPN J PHARM, 81(4), 1999, pp. 393-396

Abstract

The differential display method was used to identify the intrinsic factor that changes its mRNA expression level in rat brain after a 14-day oral administration of 20 mg/kg imipramine. The expression of a 180-bp band was markedly enhanced by imipramine. The results of sequencing and a data base search revealed that the isolated clone was glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with a one-base difference. Enhancement of the expression byimipramine was observed in the amygdala. Quantitative PCR showed that imipramine treatment significantly elevated the GAPDH/beta-actin ratio in the cortex. These findings suggest that long-term treatment with imipramine stimulates GAPDH mRNA expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 09:09:32