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Titolo:
The gonadotropin-releasing hormone family of neuropeptides in the brain ofhuman, bovine and rat: identification of a third isoform
Autore:
Yahalom, D; Chen, A; Ben-Aroya, N; Rahimipour, S; Kaganovsky, E; Okon, E; Fridkin, M; Koch, Y;
Indirizzi:
Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel Weizmann InstSci Rehovot Israel IL-76100 Chem, IL-76100 Rehovot, Israel Rabin Med Ctr, Dept Pathol, IL-49100 Petah Tiqwa, Israel Rabin Med Ctr Petah Tiqwa Israel IL-49100 , IL-49100 Petah Tiqwa, Israel
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 463, anno: 1999,
pagine: 289 - 294
SICI:
0014-5793(199912)463:3<289:TGHFON>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHICKEN GNRH-II; MOLECULAR-FORMS; GOLDFISH; HYPOTHALAMUS; RECEPTORS; SGNRH; LH;
Keywords:
gonadotropin-releasing hormone/luteinizing; hormone-releasing hormone isoform; gonadotropin-releasing hormone, third isoform in mammalian brain; salmon gonadotropin-releasing hormone-like peptide in mammals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Koch, Y Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 -76100 Rehovot, Israel
Citazione:
D. Yahalom et al., "The gonadotropin-releasing hormone family of neuropeptides in the brain ofhuman, bovine and rat: identification of a third isoform", FEBS LETTER, 463(3), 1999, pp. 289-294

Abstract

The mammalian gonadotropin-releasing hormone (GnRH-I), which regulates reproduction, was the first isoform of GnRH that was identified in mammals. Recently, me and others hale demonstrated the existence of a second isoform of GnRH in the brain of mammals. The presence of a third isoform of GnRH, GnRH-III, in the brain of mammals is reported herein. GnRH-III, extracted from the brain of bovine and human, was purified by high performance liquid chromatography, using two distinct elution programs. In both, GnRH-III nas eluted at the same positions as synthetic salmon GnRH, as demonstrated by radioimmunoassay. The luteinizing hormone-releasing activity of purified GnRH-III, using dispersed rat pituitary cells, was found to be similar to that of synthetic salmon GnRH. The total amount of GnRH-III, determined by radioimmunoassay, in the hypothalamus and midbrain of humans and calves is similar to that of GnRH-I, Immunohistochemical studies demonstrated GnRH-III-containing neurons in the hypothalamus and midbrain of human and GnRH-III fibers in the median eminence of rats. The distribution of GnRH-III in the brainsuggests that in addition to a putative function as a neurohormone at the hypothalamic-pituitary axis, GnRH-III may have other functions. Our presentresults suggest that multiple isoforms of GnRH are present in the brain ofmammals, and further studies are required in order to elucidate their biological functions. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:20:41