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Titolo:
Evaluation of ischemic injury during liver procurement from non-heart-beating donors
Autore:
Garcia-Valdecasas, JC; Tabet, J; Valero, R; Deulofeu, R; Taura, P; Rull, R; Capdevila, L; Cifuentes, A; Gonzalez, R; Net, M; Beltran, J; Lopez-Boado, MA; Palacin, J; Garcia, F;
Indirizzi:
Hosp Clin Barcelona, Dept Surg, Liver Transplant Unit, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 it, E-08036 Barcelona, Spain Hosp Clin Barcelona, Dept Anesthesiol, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 ol, E-08036 Barcelona, Spain Hosp Clin Barcelona, Dept Biochem, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 em, E-08036 Barcelona, Spain Univ Barcelona, Sch Vet Med, Dept Surg, E-08007 Barcelona, Spain Univ Barcelona Barcelona Spain E-08007 pt Surg, E-08007 Barcelona, Spain
Titolo Testata:
EUROPEAN SURGICAL RESEARCH
fascicolo: 6, volume: 31, anno: 1999,
pagine: 447 - 456
SICI:
0014-312X(199911/12)31:6<447:EOIIDL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-S-TRANSFERASE; SERUM HYALURONIC-ACID; BILIARY COMPLICATIONS; NORMOTHERMIC RECIRCULATION; HEPATOCELLULAR DAMAGE; SENSITIVE MARKER; WARM ISCHEMIA; TRANSPLANTATION; ALPHA; VIABILITY;
Keywords:
non-heart-beating donor; normothermic recirculation; liver procurement; reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Valdecasas, JC Hosp Clin Barcelona, Dept Surg, Liver Transplant Unit, Villarroel 170, E-08036 Barcelona, Spain Hosp Clin Barcelona Villarroel 170 Barcelona Spain E-08036
Citazione:
J.C. Garcia-Valdecasas et al., "Evaluation of ischemic injury during liver procurement from non-heart-beating donors", EUR SURG RE, 31(6), 1999, pp. 447-456

Abstract

The aim of this study was to assess liver viability after different periods of cardiac arrest and the predictive value of two markers of ischemia-reperfusion injury. Methods: A pig liver transplantation model of non-heart-beating donors was studied. Four donor groups were designed; three groups were submitted to different periods of cardiac arrest (20, 30 and 40 min), andthe fourth group served as the control group (without cardiac arrest). In the non-heart-beating donor groups, normothermic recirculation was established 30 min prior to total body cooling. Aminotransferase, alpha-glutathione-S-transferase, and hyaluronic acid determinations as well as liver biopsies, were serially performed. Results: Although hepatocellular function couldbe preserved after 40 min of cardiac arrest, histological lesions at 5 days were considered irreversible due to the presence of a necrotic biliary tract. An overall significant relationship was found between the time period of cardiac arrest (20, 30 or 40 min) and the levels of hyaluronic acid (p =0.004) or alpha-glutathione-S-transferase (p = 0.01) obtained during liverprocurement and transplantation. Conclusions: The period of cardiac arrestis the determinant factor of liver viability after liver transplantation from non-heart-beating donors. As early markers of endothelial or hepatocellular damage, hyaluronic acid or alpha-glutathione-S-transferase levels may help to evaluate the ischemic injury of a potential donor. Copyright (C) 1999 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:45:12