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Titolo:
Prevalence and outcome of intracranial haemorrhage in haemophiliacs - a survey of the paediatric group of the German Society of Thrombosis and Haemostasis (GTH)
Autore:
Klinge, J; Auberger, K; Auerswald, G; Brackmann, HH; Mauz-Korholz, C; Kreuz, W;
Indirizzi:
Univ Erlangen Nurnberg, Dept Paediat, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany Univ Munich, Dept Paediat, D-80539 Munich, Germany Univ Munich Munich Germany D-80539 Dept Paediat, D-80539 Munich, Germany Prof Hess Childrens Hosp, Bremen, Germany Prof Hess Childrens Hosp Bremen Germany Childrens Hosp, Bremen, Germany Univ Bonn, Haemophilia Ctr, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 onn, Haemophilia Ctr, D-5300 Bonn, Germany Univ Dusseldorf, Dept Paediat, D-4000 Dusseldorf, Germany Univ DusseldorfDusseldorf Germany D-4000 at, D-4000 Dusseldorf, Germany Univ Frankfurt, Dept Paediat, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 ediat, D-6000 Frankfurt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PEDIATRICS
, volume: 158, anno: 1999, supplemento:, 3
pagine: S162 - S165
SICI:
0340-6199(199912)158:<S162:PAOOIH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOPHILIACS;
Keywords:
haemophilia; intracranial haemorrhage; prevalence; neurological outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
4
Recensione:
Indirizzi per estratti:
Indirizzo: Klinge, J Univ Erlangen Nurnberg, Hosp Children & Adolescents, Loschgestr 15, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Loschgestr 15 Erlangen Germany D-91054 y
Citazione:
J. Klinge et al., "Prevalence and outcome of intracranial haemorrhage in haemophiliacs - a survey of the paediatric group of the German Society of Thrombosis and Haemostasis (GTH)", EUR J PED, 158, 1999, pp. S162-S165

Abstract

A survey among centres of the paediatric group of the GTH was performed toevaluate the prevalence and outcome of haemophiliacs with intracerebral haemorrhage, A questionnaire sent to the centres covered the following points: number of patients with severe, moderate and mild haemophilia A and B; for each patient with ICH: birth date, age at bleeding, aetiology and neurological sequelae. Overall, 30 ICH in 744 haemophiliacs (4.0%) were reported by 17/40 centres (42.5%). There was no significant difference between the prevalence of patients with haemophilia A and B (3.5% vs. 6.3%) and among theage groups. Bleeding was diagnosed within 1 week of birth in 11/27 patients (41%). For 3 patients, no age-related information was given. The most important factor was trauma (17/30 = 57%), either during birth (9/30 = 30%) orlater in life (8/30 = 27%). Seizures were common, occurring in 19/30 patients (63%). As 1 patient died after posttraumatic ICH, the neurological outcome of 29 patients could be evaluated. Psychomotor and statomotor retardation and cerebral palsy were reported in 17/29 (59%), 15/29 (51%) and 13/29 (45%) patients respectively. Only 7/29 (24%) showed no neurological sequelae. Severity of deficits was not correlated with birth date but to age at bleeding. Older children showed a better neurological outcome than neonates. Conclusion The frequency and outcome of ICH in haemophiliacs have not changed in our cohort over the past 20 years. Trauma at birth is an important risk factor for ICH in patients with haemophilia A or B. Intracranial haemorrhages in older children are rare, and a better outcome may be expected.

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Documento generato il 21/09/20 alle ore 06:12:27