Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Induction of stable long-term depression in vivo in the hippocampal-prefrontal cortex pathway
Autore:
Takita, M; Izaki, Y; Jay, TM; Kaneko, H; Suzuki, SS;
Indirizzi:
Natl Inst Biosci & Human Technol, Neuroinformat Lab, Tsukuba, Ibaraki 3058566, Japan Natl Inst Biosci & Human Technol Tsukuba Ibaraki Japan 3058566 566, Japan Saitama Med Sch, Dept Physiol, Moroyama, Saitama 3500495, Japan Saitama Med Sch Moroyama Saitama Japan 3500495 ma, Saitama 3500495, Japan Univ Paris 11, Lab Neurobiol Apprentissage Memoire & Commun, CNRS, UMR 8620, F-91405 Orsay, France Univ Paris 11 Orsay France F-91405 CNRS, UMR 8620, F-91405 Orsay, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 11, anno: 1999,
pagine: 4145 - 4148
SICI:
0953-816X(199911)11:11<4145:IOSLDI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFERENT FIBER SYSTEM; DIRECT PROJECTION; VISUAL-CORTEX; AMMONS HORN; RAT; POTENTIATION; NEURONS; STIMULATION; EFFERENTS; CIRCUITS;
Keywords:
CA1; field potential; prelimbic area; rats; subiculum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Takita, M Natl Inst Biosci & Human Technol, Neuroinformat Lab, 1-1 Higashi, Tsukuba,Ibaraki 3058566, Japan Natl Inst Biosci & Human Technol 1-1 Higashi Tsukuba Ibaraki Japan 3058566
Citazione:
M. Takita et al., "Induction of stable long-term depression in vivo in the hippocampal-prefrontal cortex pathway", EUR J NEURO, 11(11), 1999, pp. 4145-4148

Abstract

We studied excitatory field potentials in the medial prefrontal cortex (mPFC, prelimbic area) to electrostimulation of the ventral hippocampus (CA1/subicular region) in the anaesthetized rat. Nine hundred stimulus trains (5 pulses at 250 Hz) applied at 1 Hz to the ventral hippocampus significantly and persistently depressed the amplitude and maximal slope (similar to 55% for each index) of the prelimbic field potentials, but did not change the latency of the maximal slope or peak negativity. Twelve stimulus trains (50 pulses at 250 Hz) applied subsequently at 0.1 Hz restored the depression back to control level, and this reversible depression was maintained for at least 13 h. Cumulative depressive effects on the prelimbic field potential amplitude and maximal slope were observed upon addition of stimulus trains in the hippocampus. An important implication of the results is that the direct pathway from the hippocampus to the mPFC in the rat retains long-term depression (LTD) as a neuroplastic form in vivo. This form could cooperate with long-term potentiation (LTP) and such a bi-directional synaptic plasticity in the prefrontal cortex contributes to how cortical neural networks store information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:47:53