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Titolo:
Perirhinal cortex input to the hippocampus in the rat: evidence for parallel pathways, both direct and indirect. A combined physiological and anatomical study
Autore:
Naber, PA; Witter, MP; da Silva, FHL;
Indirizzi:
Univ Amsterdam, Fac Biol, Inst Neurobiol, Grad Sch Neurosci, NL-1098 SM Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1098 SM M Amsterdam, Netherlands Vrije Univ Amsterdam, Dept Anat & Embryol, Fac Med, Neurosci Res Inst,GradSch Neurosci, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 BT erdam, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 11, anno: 1999,
pagine: 4119 - 4133
SICI:
0953-816X(199911)11:11<4119:PCITTH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CURRENT-SOURCE-DENSITY; ENTORHINAL CORTEX; MEMORY IMPAIRMENT; TOPOGRAPHIC ORGANIZATION; POSTRHINAL CORTICES; DENTATE GYRUS; PARAHIPPOCAMPAL CORTICES; PERFORANT PATH; FIELD CA1; CONNECTIONS;
Keywords:
anterograde and retrograde tracers; area CA1; dentate gyrus; in vivo electrophysiology; lateral entorhinal cortex; learning and memory; subiculum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: da Silva, FHL Univ Amsterdam, Fac Biol, Inst Neurobiol, Grad Sch Neurosci,Kruislaan 320, NL-1098 SM Amsterdam, Netherlands Univ Amsterdam Kruislaan 320 Amsterdam Netherlands NL-1098 SM
Citazione:
P.A. Naber et al., "Perirhinal cortex input to the hippocampus in the rat: evidence for parallel pathways, both direct and indirect. A combined physiological and anatomical study", EUR J NEURO, 11(11), 1999, pp. 4119-4133

Abstract

The possibility of a direct projection from the perirhinal cortex (PER) toareas CA1 and subiculum (SUB) in the hippocampus has been suggested on thebasis of tracer studies, but this projection has not unequivocally been supported by physiological studies. The demonstration of such a functional pathway might be important to understand the functioning of the hippocampal memory system. Here we present physiological and further anatomical evidencefor such a connection between PER and the hippocampus. Electrical stimulation of PER in vivo evoked field potentials (EFPs) at the border area of CA1/SUB, consisting of a short latency and a longer latency component. Currentsource density analysis revealed that the sink of the short latency component was situated in the molecular layer of area CA1/SUB, while the longer latency component had its sink in the outer molecular layer of the dentate gyrus (DG). Anterograde tracer injections in PER showed labelled fibres in the border area of CA1/SUB, but anatomical evidence for a projection of PER to DG was not found. When synaptic transmission in the entorhinal cortex was partly blocked, the amplitude of the longer latency component of the recorded EFPs in the hippocampus was decreased while the short latency component was not affected, which suggests that the indirect pathway originating inPER is mediated through a synaptic relay in the entorhinal dorter. From the present results we conclude that information originating in PER reaches area CA1/SUB by parallel, direct and indirect, routes. The existence of thisparallel organization appears to form an essential feature for the proper function of the medial temporal lobe memory system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:48:36