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Titolo:
AMPA-receptor involvement in c-fos expression in the medial prefrontal cortex and amygdala dissociates neural substrates of conditioned activity and conditioned reward
Autore:
Mead, AN; Vasilaki, A; Spyraki, C; Duka, T; Stephens, DN;
Indirizzi:
Univ Sussex, Sch Biol Sci, Expt Psychol Lab, Brighton BN1 9QG, E Sussex, England Univ Sussex Brighton E Sussex England BN1 9QG BN1 9QG, E Sussex, England Univ Crete, Sch Med, Pharmacol Lab, Heraklion, Greece Univ Crete Heraklion Greece , Sch Med, Pharmacol Lab, Heraklion, Greece
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 11, anno: 1999,
pagine: 4089 - 4098
SICI:
0953-816X(199911)11:11<4089:AIICEI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IBOTENIC ACID LESIONS; IMMEDIATE-EARLY GENES; PLACE PREFERENCE; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; BASOLATERAL AMYGDALA; EXCITOTOXIC LESIONS; CHRONIC AMPHETAMINE; STRIATAL NEURONS; ANTAGONIST NBQX;
Keywords:
amphetamine; conditioned place preference; mouse; nucleus accumbens; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Stephens, DN Univ Sussex, Sch Biol Sci, Expt Psychol Lab, Brighton BN1 9QG, E Sussex, England Univ Sussex Brighton E Sussex England BN1 9QG ussex, England
Citazione:
A.N. Mead et al., "AMPA-receptor involvement in c-fos expression in the medial prefrontal cortex and amygdala dissociates neural substrates of conditioned activity and conditioned reward", EUR J NEURO, 11(11), 1999, pp. 4089-4098

Abstract

Exposure to an environment, previously conditioned to amphetamine (1 mg/kg, i.p.), induced locomotor activity and c-fos expression (a marker for neuronal activation) in the mouse medial prefrontal cortex (mPFC) and amygdala;acute or repeated amphetamine (1 mg/kg, i.p.) administration induced c-fosexpression additionally in the nucleus accumbens. An alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline (NBQX), blocked expression of conditioned activity, and prevented the increase in c-fos expression in mPFC, implicating mPFC AMPAergic transmission in the conditioned component of behavioural sensitization to amphetamine. NBQX failed to block the expression of amphetamine-conditioned place preference, a measure of conditioned reward, or conditioned c-fos expression in the amygdala, an area implicated in the expression of conditioned place preference. These findings indicate that the conditioned components of behavioural sensitization depend on AM PA-receptor-mediated activation in mPFC, but that conditioned reward does not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 01:39:07