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Titolo:
Clinical utility of simultaneous measurement of serum high-sensitivity des-gamma-carboxy prothrombin and Lens culinaris agglutinin A-reactive alpha-fetoprotein in patients with small hepatocellular carcinoma
Autore:
Sassa, T; Kumada, T; Nakano, S; Uematsu, T;
Indirizzi:
Gifu Univ, Sch Med, Dept Pharmacol, Gifu 500, Japan Gifu Univ Gifu Japan500 Univ, Sch Med, Dept Pharmacol, Gifu 500, Japan
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 12, volume: 11, anno: 1999,
pagine: 1387 - 1392
SICI:
0954-691X(199912)11:12<1387:CUOSMO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LECTIN AFFINITY ELECTROPHORESIS; ABNORMAL PROTHROMBIN; FOLLOW-UP; ENZYME-IMMUNOASSAY; EARLY DIAGNOSIS; LIVER-DISEASE; PIVKA-II; ANGIOGRAPHY; MARKER; CARBOXYPROTHROMBIN;
Keywords:
high-sensitivity des-gamma-carboxy prothrombin (H-DCP); Lens culinaris agglutinin A-reactive alpha-fetoprotein (AFP-LS); simultaneous measurement; small hepatocellular carcinoma (HCC);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kumada, T Ogaki Municipal Hosp, Dept Gastroenterol, 4-86 Minaminokawa Cho,Gifu 5030864, Japan Ogaki Municipal Hosp 4-86 Minaminokawa Cho Gifu Japan5030864 n
Citazione:
T. Sassa et al., "Clinical utility of simultaneous measurement of serum high-sensitivity des-gamma-carboxy prothrombin and Lens culinaris agglutinin A-reactive alpha-fetoprotein in patients with small hepatocellular carcinoma", EUR J GASTR, 11(12), 1999, pp. 1387-1392

Abstract

Objective To evaluate the diagnostic efficacy of simultaneous measurementsof high-sensitivity des-gamma-carboxy prothrombin (H-DCP) and Lens culinaris agglutinin A-reactive a-fetoprotein (AFP-L3) in small hepatocellular carcinoma (HCC). Methods Sixty-one patients with small HCCs less than or equal to 2 cm in diameter and 134 controls (chronic hepatitis: 59 cases; cirrhosis: 75 cases)were examined. H-DCP was measured by electrochemiluminescence immunoassay (cut-off 40 mAU/ml (milli-arbitrary units/ml) and AFP-L3% (percentage of AFP-L3/total AFP) by lectin-affinity electrophoresis coupled with the antibody-affinity blotting method (cut-off 10%). Fifty-six patients were histologically diagnosed and the remaining five patients were diagnosed clinically. Results Of 61 patients, 27 (44.3%) were positive for H-DCP and 14 (23.0%) were positive for AFP-LB. There was no correlation between H-DCP and AFP-L3%. Nineteen patients (31.1%) had positive H-DCP alone. Six patients (9.8%) had positive AFP-L3 alone, and in eight patients (13.1%) both markers were positive. In combination assay, 33 of 61 patients (54.1%) were positive foreither marker; specificity and accuracy were 97.8% and 84.1%, respectively. There was a tendency for the AFP-L3% to be elevated in patients with moderately or poorly differentiated HCC (P = 0.0564) and multiple HCC nodules (P = 0.0316), while the H-DCP showed no elevation related to the tumour type. Conclusion The detection rate of small HCC was improved by combination assay with H-DCP and AFP-L3%. Our results indicate that the markers are complementary and useful for the diagnosis and evaluation of small HCC when measured simultaneously. fur I Gastroenterol Hepatol 11:1387-1392 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:11:01