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Titolo:
Pleuropneumonectomy in the treatment of malignant pleural mesothelioma
Autore:
Grondin, SC; Sugarbaker, DJ;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Thorac Surg, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 d, Div Thorac Surg, Boston, MA 02115 USA
Titolo Testata:
CHEST
fascicolo: 6, volume: 116, anno: 1999, supplemento:, S
pagine: 450S - 454S
SICI:
0012-3692(199912)116:6<450S:PITTOM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
188 CONSECUTIVE PATIENTS; MULTIMODALITY THERAPY; DNA-SEQUENCES; THORACOSCOPY; DIAGNOSIS; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sugarbaker, DJ Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA 02115 MA 02115 USA
Citazione:
S.C. Grondin e D.J. Sugarbaker, "Pleuropneumonectomy in the treatment of malignant pleural mesothelioma", CHEST, 116(6), 1999, pp. 450S-454S

Abstract

Study objectives: Malignant pleural mesothelioma (MPM) is predominantly a local/regional disease that results in a survival time that ranges from 4 to 12 months without treatment. Single-modality therapy using surgery, chemotherapy, or radiotherapy alone is largely ineffective. The objective of thestudy was presentation of the use of pleuropneumonectomy in a multimodality treatment setting and the results. Design: Didactic presentation. Setting: Academic tertiary-care hospital. Patients: One hundred eighty-three patients who underwent multimodality therapy. Interventions: Of all the single-modality treatment approaches, pleuropneumonectomy has been associated most consistently with long-term disease-freesurvival and has provided the greatest amount of tumor cytoreduction. The technique of pleuropneumonectomy traditionally has been linked with high perioperative mortality and morbidity when compared with that of other cytoreductive techniques such as pleurectomy/decortication. Recently, improvements in operative mortality (< 5%) have been reported, largely due to improvements in patient selection and perioperative management. Multimodality therapy, including chemotherapy, radiotherapy, and extrapleural pneumonectomy, was used to treat patients. Results: Outcomes were presented for 183 patients with MPM who underwent multimodality therapy,Conclusions: With the development of multimodality therapy, pleuropneumonectomy followed by sequential chemotherapy and radiotherapy has demonstrateda significant survival benefit, especially for patients who have epithelial tumor histology, tumor free resection margins, and tumor-free extrapleural node status.

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Documento generato il 04/12/20 alle ore 16:21:09