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Titolo:
Mu opioid receptors are in somatodendritic and axonal compartments of GABAergic neurons in rat hippocampal formation
Autore:
Drake, CT; Milner, TA;
Indirizzi:
Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 rol & Neurosci, New York, NY 10021 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 849, anno: 1999,
pagine: 203 - 215
SICI:
0006-8993(199912)849:1-2<203:MORAIS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ULTRASTRUCTURAL IMMUNOCYTOCHEMICAL LOCALIZATION; GABA-CONTAINING NEURONS; LATERAL PERFORANT PATH; DENTATE GYRUS; PYRAMIDAL CELLS; GUINEA-PIG; IMMUNOHISTOCHEMICAL LOCALIZATION; CHOLINERGIC INNERVATION; INHIBITORY INTERNEURONS;
Keywords:
electron microscopy; ultrastructure; hippocampus; dentate gyrus; interneuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Drake, CT Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, 411 E69th St, New York, NY 10021 USA Cornell Univ 411 E 69th St New York NY USA 10021 k, NY 10021 USA
Citazione:
C.T. Drake e T.A. Milner, "Mu opioid receptors are in somatodendritic and axonal compartments of GABAergic neurons in rat hippocampal formation", BRAIN RES, 849(1-2), 1999, pp. 203-215

Abstract

Activation of mu opioid receptors (MORs) has a net excitatory effect in the hippocampal formation through inhibition of gamma-amino butyric acid (GABA)-containing interneurons. To determine the precise subcellular targets ofMOR agonists, immunoreactivity against MOR1 and GABA was examined in single sections of the hippocampal formation prepared for dual-labeling electronmicroscopy. In both the CA1 region of hippocampus and the dentate gyrus, MOR-Like immunoreactivity (-li) was present in neuronal somata, dendrites, axons, and axon terminals, as well as a very few glial processes. Axon terminals with MOR-li formed symmetric synapses with principal cell dendrites and somata. Many MOR-labeled profiles of all types also contained GABA-li, and the vast majority possessed the ultrastructural characteristics of interneurons. Additionally, in the dentate gyrus a very small proportion of granule cell dendrites contained MOR-li. MOR-U, identified using immunogold-silver particles, was often affiliated with the extrasynaptic regions of neuronal plasma membranes, consistent with responsiveness to diffusing endogenousneuropeptide ligands. Semiquantitative analysis of the distribution of MOR-li revealed significantly more "presynaptic" (axons and terminals) than "postsynaptic" (somata and dendrites) labeled profiles in most laminae. We conclude that in addition to previously described somatodendritic MOR-li, a substantial amount of MOR-II in hippocampal formation is presynaptic. Furthermore, MORs are almost exclusively in GABAergic interneurons. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:43:34