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Titolo:
Effects of local infusions of dopaminergic drugs into the medial prefrontal cortex of rats on latent inhibition, prepulse inhibition and amphetamine induced activity
Autore:
Lacroix, L; Broersen, LM; Feldon, J; Weiner, I;
Indirizzi:
Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach, SwitzerlandSwiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland Grad Sch Neurosci Amsterdam, Netherlands Inst Brain Res, NL-1105 AZ Amsterdam, Netherlands Grad Sch Neurosci Amsterdam Amsterdam Netherlands NL-1105 AZ Netherlands Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 sychol, IL-69978 Tel Aviv, Israel
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 107, anno: 2000,
pagine: 111 - 121
SICI:
0166-4328(200001)107:1-2<111:EOLIOD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC ATTENTION DISORDER; ACOUSTIC STARTLE RESPONSE; NUCLEUS-ACCUMBENS CORE; 6-HYDROXYDOPAMINE LESIONS; MESOLIMBIC DOPAMINE; CIRCLING BEHAVIOR; ANIMAL-MODEL; UNILATERAL MICROINJECTIONS; INDUCED LOCOMOTION; RELEASE;
Keywords:
prepulse inhibition; latent inhibition; locomotor activity; medial prefrontal cortex; dopamine; apomorphine; amphetamine; cis-flupenthixol; schizophrenia; animal model; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Biol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
L. Lacroix et al., "Effects of local infusions of dopaminergic drugs into the medial prefrontal cortex of rats on latent inhibition, prepulse inhibition and amphetamine induced activity", BEH BRA RES, 107(1-2), 2000, pp. 111-121

Abstract

Impaired ability to 'gate out' sensory and cognitive information is considered to be a central feature of schizophrenia and is manifested, among others, in disrupted prepulse inhibition (PPI) and latent inhibition (LI). The present study investigated in rats the effects of increasing or decreasing dopamine (DA) receptor activation within the medial prefrontal cortex (mPFC) by local administration of the indirect DA receptor agonist amphetamine (AMPH; 10.0 mu g/side) or the DA antagonist cis-flupenthixol (FLU; 12.0 mu g/side) on PPI and LI as well as on systemic AMPH-induced activity. The effects of intra-mPFC apomorphine (APO; 10.0 mu g/side) on PPI were also tested. AMPH infusions decreased systemic AMPH-inddced increase in locomotor activity in the open held, whereas FLU infusion was ineffective. Both infusionshad no effect on LI and PPI. However, APO infusions induced a disruption of PPI. These results provide additional evidence that the mPFC is a component of the neural circuitry mediating PPI but plays no role in LI. In addition, they show that the behavioral outcomes produced by DA receptor activation/blockade in the mPFC of the rat cannot be explained by postulating a simple reciprocal relationship between the cortical and subcortical DA systems. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:22:17