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Titolo:
Dissociating context and space within the hippocampus: Effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning
Autore:
Richmond, MA; Yee, BK; Pouzet, B; Veenman, L; Rawlins, JNP; Feldon, J; Bannerman, DM;
Indirizzi:
Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England Univ Hong Kong, Dept Anat, Ctr Res Neurosci, Hong Kong, Hong Kong Univ Hong Kong Hong Kong Hong Kong r Res Neurosci, Hong Kong, Hong Kong Swiss Fed Inst Technol, Behav Biol Lab, Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland erzenbach, Switzerland
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 6, volume: 113, anno: 1999,
pagine: 1189 - 1203
SICI:
0735-7044(199912)113:6<1189:DCASWT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONFIGURAL ASSOCIATION THEORY; NUCLEUS-ACCUMBENS; IBOTENIC ACID; FEAR; RATS; AMYGDALA; AMNESIA; CORTEX; SUPPRESSION; COMPONENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Rawlins, JNP Univ Oxford, Dept Expt Psychol, S Parks Rd, Oxford OX1 3UD, England Univ Oxford S Parks Rd Oxford England OX1 3UD 1 3UD, England
Citazione:
M.A. Richmond et al., "Dissociating context and space within the hippocampus: Effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning", BEHAV NEURO, 113(6), 1999, pp. 1189-1203

Abstract

Rats with complete excitotoxic hippocampal lesions or selective damage to the dorsal or ventral hippocampus were compared with controls on measures of contextually conditioned freezing in a signaled shock procedure and on a spatial water-maze task. Complete and ventral lesions produced equivalent, significant anterograde deficits in conditioned freezing relative to both dorsal lesions and controls. Complete hippocampal lesions impaired water-maze performance; in contrast, ventral lesions improved performance relative to the dorsal group, which was itself unexpectedly unimpaired relative to controls. Thus, the partial lesion effects seen in the 2 tasks never resembled each other. Anterograde impairments in contextual freezing and spatial learning do not share a common underlying neural basis; complete and ventral lesions may induce anterograde contextual freezing impairments by enhancinglocomotor activity under conditions of mild stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:21:31