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Titolo:
Determinants of attrition in a natural history study of Alzheimer disease
Autore:
Koss, E; Peterson, B; Fillenbaum, GG;
Indirizzi:
Case Western Reserve Univ, Univ Hosp, Alzheimer Ctr, Cleveland, OH USA Case Western Reserve Univ Cleveland OH USA heimer Ctr, Cleveland, OH USA Duke Univ, Med Ctr, Dept Community & Family Med, Div Biometry, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 ily Med, Div Biometry, Durham, NC 27710 USA Duke Univ, Med Ctr, Ctr Study Aging & Human Dev, Durham, NC 27710 USA DukeUniv Durham NC USA 27710 udy Aging & Human Dev, Durham, NC 27710 USA
Titolo Testata:
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
fascicolo: 4, volume: 13, anno: 1999,
pagine: 209 - 215
SICI:
0893-0341(199910/12)13:4<209:DOAIAN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMUNITY SURVEY; OLDER ADULTS; DEMENTIA; CERAD; CONSORTIUM; ESTABLISH; REGISTRY; EXPERIENCE; PREDICTORS;
Keywords:
Alzheimer disease; attrition; longitudinal; natural history;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Koss, E Dept Psychiat, 11100 Euclid Ave, Cleveland, OH 44106 USA Dept Psychiat 11100 Euclid Ave Cleveland OH USA 44106 OH 44106 USA
Citazione:
E. Koss et al., "Determinants of attrition in a natural history study of Alzheimer disease", ALZ DIS A D, 13(4), 1999, pp. 209-215

Abstract

The aim of the present study was to identify determinants of attrition in a natural history study of a tertiary care sample of patients with Alzheimer disease (AD) and control subjects. A longitudinal study was performed with 978 patients with AD and 466 control subjects age 50 years and older enrolled at 25 sites of the Consortium to Establish a Registry for Alzheimer's Disease between January 1987 and January 1992; subjects were followed annually for up to 78 months. Both descriptive statistics and polytomous logistic regressions were run to identify determinants of attrition. Of the 1,444 subjects enrolled, 10.5% dropped out after initial evaluation, 31.0% provided at least two waves of data, and 58.4% provided complete follow-up. Inadequate involvement by the site, non-white status, and patient's spouse not enrolled in the study were predictive of dropout; cessation of participationbecause of death (which may have precluded dropout) predicted continuationin the study. Age, level of education, severity of dementia, and rapidity of progression of disease did not predict dropout. Level-of-site commitmentwas the most significant determinant of continued participation in this natural history study of AD, followed by white race, and the inclusion of both husband and wife where one is a patient and the other a control subject.

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Documento generato il 22/09/20 alle ore 16:15:17