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Titolo:
Sensory gating in rats: Lack of correlation between auditory evoked potential gating and prepulse inhibition
Autore:
Ellenbroek, BA; van Luijtelaar, G; Frenken, M; Cools, AR;
Indirizzi:
Univ Nijmegen, Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, NetherlandsUniv Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 4, volume: 25, anno: 1999,
pagine: 777 - 788
SICI:
0586-7614(1999)25:4<777:SGIRLO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; LATENT INHIBITION; CHRONIC-SCHIZOPHRENICS; MODEL; PHENCYCLIDINE; AMPHETAMINE; MODULATION; SYSTEM;
Keywords:
sensory gating; auditory evoked potential; acoustic startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ellenbroek, BA Univ Nijmegen, Dept Psychoneuropharmacol, POB 9101, NL-6500HB Nijmegen, Netherlands Univ Nijmegen POB 9101 Nijmegen Netherlands NL-6500 HB nds
Citazione:
B.A. Ellenbroek et al., "Sensory gating in rats: Lack of correlation between auditory evoked potential gating and prepulse inhibition", SCHIZO BULL, 25(4), 1999, pp. 777-788

Abstract

This study was designed to evaluate the possible similarities between two paradigms designed to measure sensory gating: (1) an auditory evoked potential (AEP), called the P-50 gating paradigm; and (2) an acoustic startle (ASR), called the prepulse inhibition paradigm. These paradigms show a number of methodological, pharmacological, and neurobiological similarities, and they are both disturbed in patients with schizophrenia. In the first of three experiments, the AEP gating and the ASR gating were measured in rats. Although both AEP and ASR gating could readily be obtained, there appeared to be no correlation between the performance in these two paradigms. This lackof correlation was confirmed using a factor analytical approach, where theAEP gating and the ASR gating parameters were found to load on different factors. In the second experiment, the interstimulus interval in the ASR paradigm was increased to 500 ms (identical to the interstimulus interval of the AEP gating paradigm). This increase reduced the degree of ASR gating, although some gating could still be obtained. Again no correlation was found between AEP and ASR gating, and this was again confirmed by the factorial analysis. In the final experiment, the effects of the dopamine D-2/3 agonist7-OHDPAT were evaluated in both paradigms. This selective agonist dose dependently reduced ASR gating but had no effect on AEP gating. Together, these data strongly suggest that AEP and ASR gating measure two different aspects of information processing and indicate that both paradigms may be important for investigating the neurobiological disturbances observed in patientswith psychoses.

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Documento generato il 25/01/20 alle ore 15:37:30