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Titolo:
Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography
Autore:
Llinas, RR; Ribary, U; Jeanmonod, D; Kronberg, E; Mitra, PP;
Indirizzi:
NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA NYU New York NY USA 10016 Dept Physiol & Neurosci, New York, NY 10016 USA Univ Spital Zurich, Neurochirurg Klin, CH-8091 Zurich, Switzerland Univ Spital Zurich Zurich Switzerland CH-8091 H-8091 Zurich, Switzerland Bell Labs, Lucent Technol, Murray Hill, NJ 07974 USA Bell Labs Murray Hill NJ USA 07974 ent Technol, Murray Hill, NJ 07974 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 26, volume: 96, anno: 1999,
pagine: 15222 - 15227
SICI:
0027-8424(199912)96:26<15222:TDANAN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; ELECTROPHYSIOLOGICAL PROPERTIES; ASSOCIATION CORTEX; BRAIN ACTIVITY; VISUAL-CORTEX; RELAY NEURONS; 2 PARTS; OSCILLATIONS; SYNCHRONIZATION; CAT;
Keywords:
edge effect; theta activity; gamma activity; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Llinas, RR NYU, Sch Med, Dept Physiol & Neurosci, 550 1st Ave, New York, NY 10016 USA NYU 550 1st Ave New York NY USA 10016 e, New York, NY 10016 USA
Citazione:
R.R. Llinas et al., "Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography", P NAS US, 96(26), 1999, pp. 15222-15227

Abstract

Spontaneous magnetoencephalographic activity was recorded in awake, healthy human controls and in patients suffering from neurogenic pain, tinnitus, Parkinson's disease, or depression. Compared with controls, patients showedincreased low-frequency a rhythmicity, in conjunction with a widespread and marked increase of coherence among high- and low-frequency oscillations. These data indicate the presence of a thalamocortical dysrhythmia, which wepropose is responsible for all the above mentioned conditions. This coherent a activity, the result of a resonant interaction between thalamus and cortex, is due to the generation of low-threshold calcium spike bursts by thalamic cells. The presence of these bursts is directly related to thalamic cell hyperpolarization, brought about by either excess inhibition or disfacilitation. The emergence of positive clinical symptoms is viewed as resulting from ectopic gamma-band activation, which we refer to as the "edge effect. " This effect is observable as increased coherence between low- and high-frequency oscillations, probably resulting from inhibitory asymmetry betweenhigh- and low-frequency thalamocortical modules at the cortical level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:34:56