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Titolo:
Developmental dissociation of thymic dendritic cell and thymocyte lineagesrevealed in growth factor receptor mutant mice
Autore:
Rodewald, HR; Brocker, T; Haller, C;
Indirizzi:
Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 26, volume: 96, anno: 1999,
pagine: 15068 - 15073
SICI:
0027-8424(199912)96:26<15068:DDOTDC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-KIT; SURFACE-MARKERS; MOUSE THYMUS; GAMMA CHAIN; T-CELL; EXPRESSION; LYMPHOCYTES; MATURATION; SPLEEN; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Rodewald, HR Univ Klin, D-89081 Ulm, Germany Univ Klin Ulm Germany D-89081 iv Klin, D-89081 Ulm, Germany
Citazione:
H.R. Rodewald et al., "Developmental dissociation of thymic dendritic cell and thymocyte lineagesrevealed in growth factor receptor mutant mice", P NAS US, 96(26), 1999, pp. 15068-15073

Abstract

Thymocytes and thymic dendritic cell (DC) lineages develop simultaneously and may originate from a common intrathymic progenitor. Mice deficient for two growth factor receptor molecules [c-kit and the common cytokine receptor gamma chain (gamma(c))] lack all thymocytes including T cell progenitors. Despite this lack of pro-T cells, thymic DC compartments were identified in c-kit(-)gamma c(-) mice. Thus, c-kit- and gamma(c)-mediated signals are not essential to generate thymic DCs. In addition, pro-T cells do not appearto be obligatory progenitors of thymic DCs, because DC development is dissociated from the generation of thymocytes in these mice. Thymic DCs in c-kit(-)gamma c(-) mice are phenotypically and functionally normal. In contrastto wild-type mice, however, thymic DCs in c-kit(-)gamma c(-) and, notably,in RAG-2-deficient mice are CD8 alpha(neg/low), indicating that CD8 alpha expression on thymic DCs is not independent of thymocytes developing beyondthe "RAC-block".

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Documento generato il 27/11/20 alle ore 10:19:02