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Titolo:
CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat
Autore:
Kuo, MF; Wu, RM; Wang, HS; Lin, SM;
Indirizzi:
Chang Gung Childrens Hosp, Div Neurol, Tao Yuan 333, Taiwan Chang Gung Childrens Hosp Tao Yuan Taiwan 333 urol, Tao Yuan 333, Taiwan Natl Taiwan Univ Hosp, Dept Neurosurg, Taipei, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan osp, Dept Neurosurg, Taipei, Taiwan Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan v Hosp, Dept Neurol, Taipei, Taiwan
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 35, anno: 1999,
pagine: 347 - 350
SICI:
0168-0102(199912)35:4<347:CAHCID>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; FOCAL CEREBRAL-ISCHEMIA; ADULT-RATS; BLOOD-FLOW; RELEASE; BRAIN; MICRODIALYSIS; PIGLETS;
Keywords:
NMDA receptor antagonist; CPP; striatum; hypoxia; dopamine; newborn rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, HS Chang Gung Childrens Hosp, Div Neurol, Tao Yuan 333, Taiwan ChangGung Childrens Hosp Tao Yuan Taiwan 333 Yuan 333, Taiwan
Citazione:
M.F. Kuo et al., "CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat", NEUROSCI RE, 35(4), 1999, pp. 347-350

Abstract

Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP),a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even afterthe hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:44:07