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Titolo:
Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein
Autore:
Dodart, JC; Mathis, C; Bales, KR; Paul, SM; Ungerer, A;
Indirizzi:
Univ Strasbourg 1, Lab Ethol & Neurobiol, CNRS, UMR 1295, F-67000 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67000 , F-67000 Strasbourg, France Eli Lilly & Co, Lilly Res Labs, Div Neurosci, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 osci, Indianapolis, IN 46285 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 277, anno: 1999,
pagine: 49 - 52
SICI:
0304-3940(199912)277:1<49:ERCGHI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; MEMORY CONSOLIDATION; LIPID-PEROXIDATION; PARIETAL CORTEX; SPATIAL WORKING; LESIONS; RATS; HIPPOCAMPAL; INVOLVEMENT; IMPAIRMENT;
Keywords:
Alzheimer's disease; transgenic mice; [C-14]2-deoxyglucose; beta-amyloid precursor protein; brain glucose metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dodart, JC Univ Strasbourg 1, Lab Ethol & Neurobiol, CNRS, UMR 1295, 7 RueUniv, F-67000 Strasbourg, France Univ Strasbourg 1 7 Rue Univ Strasbourg France F-67000 France
Citazione:
J.C. Dodart et al., "Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein", NEUROSCI L, 277(1), 1999, pp. 49-52

Abstract

In the present study, we examined whether the relative levels of regional brain [C-14]2-deoxyglucose (2-DG) uptake are altered in a transgenic mouse model of Alzheimer's disease which overexpresses a mutated form of the human beta-amyloid precursor protein (mutation V717F). We show that the relative levels of 2-DG uptake are significantly reduced in the septum, thalamus, dentate gyrus and parietal cortex of 3-month-old transgenic mice as compared with wild-type littermates. In 10-month-old transgenic mice, these alterations also extend to the CA3 hippocampal region, the cingulate, retrosplenial, occipital and temporal cortices, suggesting an age-dependent decrease in the regional 2-DG uptake. These results suggest that expression of a mutated APP gene induces an early regional cerebral hypometabolism independently of amyloid deposition per se. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 04:09:22