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Titolo:
BEHAVIORAL AND NEUROCHEMICAL RECOVERY FROM PARTIAL 6-HYDROXYDOPAMINE LESIONS OF THE SUBSTANTIA-NIGRA IS BLOCKED BY DAILY TREATMENT WITH D1 D5, BUT NOT D2, DOPAMINE-RECEPTOR ANTAGONISTS/
Autore:
EMMI A; RAJABI H; STEWART J;
Indirizzi:
CONCORDIA UNIV,DEPT PSYCHOL,CTR STUDIES BEHAV NEUROBIOL,1455 MAISONNEUVE BLVD W MONTREAL PQ H3G 1M8 CANADA CONCORDIA UNIV,DEPT PSYCHOL,CTR STUDIES BEHAV NEUROBIOL MONTREAL PQ H3G 1M8 CANADA
Titolo Testata:
The Journal of neuroscience
fascicolo: 10, volume: 17, anno: 1997,
pagine: 3840 - 3846
SICI:
0270-6474(1997)17:10<3840:BANRFP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; NEONATAL 6-OHDA-LESIONED RATS; PARS RETICULATA NEURONS; EXCITATORY AMINO-ACIDS; EXTRACELLULAR DOPAMINE; NUCLEUS-ACCUMBENS; TIME-COURSE; SYSTEMIC AMPHETAMINE; SENSITIZES RATS;
Keywords:
SUBSTANTIA NIGRA; 6-OHDA LESIONS; BEHAVIORAL RECOVERY; STRIATAL DOPAMINE; MICRODIALYSIS; D1/D5 RECEPTOR ANTAGONISTS; D2 RECEPTOR ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
A. Emmi et al., "BEHAVIORAL AND NEUROCHEMICAL RECOVERY FROM PARTIAL 6-HYDROXYDOPAMINE LESIONS OF THE SUBSTANTIA-NIGRA IS BLOCKED BY DAILY TREATMENT WITH D1 D5, BUT NOT D2, DOPAMINE-RECEPTOR ANTAGONISTS/", The Journal of neuroscience, 17(10), 1997, pp. 3840-3846

Abstract

To determine whether D1/D5 dopamine (DA) receptors play a role in normalization of DA extracellular levels of striatal DA and behavioral recovery after partial 6-OHDA lesions of the substantia nigra, animals were treated on days 1-8 after lesioning with the D1/D5 DA receptor antagonists SCH 23390 (0.1 mg/kg, s.c.) and SCH 39166 (1.0 mg/kg, s.c.), the inactive enantiomer SCH 23388 (0.1 mg/kg, s.c.), the D2 antagonisteticlopride(0.1 mg/kg, i.p.), or saline. Spontaneous turning behaviorwas assessed on days 3 and 15. Basal extracellular DA and metaboliteswere measured in both striata using microdialysis on days 16 and 17, 8-9 d after termination of drug treatments. On day 3, all animals turned ipsilateral to the lesion. On day 15, animals previously treated with either saline, eticlopride, or SCH 23388 showed no behavioral asymmetries, whereas animals treated with SCH 23390 or SCH 39166 turned ipsilaterally. On days 16 and 17, extracellular DA did not differ on the two sides in animals treated with saline or eticlopride and were higher on the lesioned side after SCH 23388. In animals treated with the D1/D5 receptor antagonists, however, basal levels of DA were lower on the lesioned side, showing no evidence of normalization. These results suggest a role for the D1/D5 DA receptor in the development of compensatory changes in the DA neurons that accompany behavioral recovery frompartial lesions of nigrostriatal DA system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:52:23