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Titolo:
TIMING OF THE CRITICAL PERIOD FOR PLASTICITY OF OCULAR DOMINANCE COLUMNS IN MACAQUE STRIATE CORTEX
Autore:
HORTON JC; HOCKING DR;
Indirizzi:
UNIV CALIF SAN FRANCISCO,BECKMAN VIS CTR,10 KIRKHAM ST SAN FRANCISCO CA 94143
Titolo Testata:
The Journal of neuroscience
fascicolo: 10, volume: 17, anno: 1997,
pagine: 3684 - 3709
SICI:
0270-6474(1997)17:10<3684:TOTCPF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GENICULATE-NUCLEUS; CATS VISUAL-CORTEX; CYTOCHROME-OXIDASE HISTOCHEMISTRY; CONGENITAL UNILATERAL CATARACT; MONOCULAR DEPRIVATION; SENSITIVE PERIOD; TRANSNEURONAL TRANSPORT; POSTNATAL-DEVELOPMENT; COMPLETE PATTERN; SQUIRREL-MONKEY;
Keywords:
OCULAR DOMINANCE COLUMN; COLUMN PERIOD; AMBLYOPIA; VISUAL DEPRIVATION; CYTOCHROME OXIDASE PATCH; FLAT-MOUNT; STRIATE CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Horton e D.R. Hocking, "TIMING OF THE CRITICAL PERIOD FOR PLASTICITY OF OCULAR DOMINANCE COLUMNS IN MACAQUE STRIATE CORTEX", The Journal of neuroscience, 17(10), 1997, pp. 3684-3709

Abstract

Visual deprivation induced by monocular eyelid suture, a laboratory model for congenital cataract, results in shrinkage of ocular dominancecolumns serving the closed eye. We performed monocular suture in macaques at ages 1, 3, 5, 7, and 12 weeks to define the critical period for plasticity of ocular dominance columns. After a minimum survival of 8 months, complete montages of [H-3]proline-labeled columns were reconstructed from flat-mounts of striate cortex in both hemispheres. In any given monkey, visual deprivation induced the columns throughout striate cortex (V1) to retract the same distance from their original borders in layer IVc beta. After deprivation, the widest columns remained in the foveal representation and along the V1/V2 border, where columns are widest in control animals. The narrowest deprived columns belongedto the ipsilateral eye, especially along the horizontal meridian and in the periphery, where columns are narrowest in control animals. At the earliest age that we tested (1 week), visual deprivation reduced the columns to fragments. These fragments always coincided with a cytochrome oxidase patch, or a short string of patches, in the upper layers. More severe column shrinkage occurred in layer IVc beta (parvo) than layer IVc alpha (magno). The geniculate input to the patches in layer III (konio) appeared normal after deprivation, despite loss of CO activity. Surprisingly, the blind spot representation of the open eye was shrunken by monocular deprivation, although binocular competition is absent in this region. Our principal finding was that eyelid suture at age 1 week caused the most severe column shrinkage. With suture at later ages, the degree of column shrinkage showed a progressive decline. Deprivation commencing at age 12 weeks caused no column shrinkage. These results imply that primate visual cortex is most vulnerable to deprivation during the first weeks of life. Our experiments should providefurther impetus for the treatment of children with congenital cataract at the earliest possible age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:32:57