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Titolo:
Diminished acoustic startle in chronic cocaine users
Autore:
Efferen, TR; Duncan, EJ; Szilagyi, S; Chakravorty, S; Adams, JU; Gonzenbach, S; Angrist, B; Butler, PD; Rotrosen, J;
Indirizzi:
Vet Affairs Med Ctr, Dept Psychiat 116A, New York, NY 10010 USA Vet Affairs Med Ctr New York NY USA 10010 at 116A, New York, NY 10010 USA NYU, Sch Med, New York, NY USA NYU New York NY USANYU, Sch Med, New York, NY USA Univ Pittsburgh, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USAUniv Pittsburgh, Pittsburgh, PA USA Western Psychiat Inst & Clin, Pittsburgh, PA USA Western Psychiat Inst & Clin Pittsburgh PA USA Clin, Pittsburgh, PA USA Nathan S Kline Inst Psychiat Res, New York, NY USA Nathan S Kline Inst Psychiat Res New York NY USA t Res, New York, NY USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 22, anno: 2000,
pagine: 89 - 96
SICI:
0893-133X(200001)22:1<89:DASICC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT PREPULSE INHIBITION; RAT NUCLEUS-ACCUMBENS; EXTRACELLULAR DOPAMINE; RECEPTOR AVAILABILITY; 5-HT MODULATION; WISTAR RATS; SEROTONIN; ABSTINENCE; BRAIN; TRANSPORTERS;
Keywords:
cocaine; acoustic startle; dopamine; prepulse inhibition; gating; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Duncan, EJ Vet Affairs Med Ctr, Dept Psychiat 116A, 423 E 23rd St, New York, NY 10010USA Vet Affairs Med Ctr 423 E 23rd St New York NY USA 10010 0010USA
Citazione:
T.R. Efferen et al., "Diminished acoustic startle in chronic cocaine users", NEUROPSYCH, 22(1), 2000, pp. 89-96

Abstract

Chronic cocaine use has been shown to produce neurochemical alterations which persist after acute withdrawal. This study assessed the effects of cocaine use on the acoustic startle response and sensorimotor gating using prepulse inhibition (PPI) of startle. Nine male control subjects (mean age = 41.6) and 15 male cocaine users (mean age = 43.2) were tested, the latter after heavy cocaine use ranging from 4 to 27 years (mean age = 16.7). cocaine users had been cocaine free for four days to six months (mean = 17 days) attesting. Cocaine users exhibited a 68% reduction in startle amplitudes (F = 7.4; df = 1,22; p < .01) compared to controls. There were trends towards increased PPI in cocaine users under certain conditions; however, there were not significant main effects. These results indicate that chronic cocaineuse produces impairment of the startle response which persists after cessation of cocaine use. These findings may reflect changes in the dopaminergicsystem resulting from chronic cocaine use. [Neuropsychopharmacology 22;89-96, 2000] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:53:01