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Titolo:
Effects on mood of acute phenylalanine/tyrosine depletion in healthy women
Autore:
Leyton, M; Young, SN; Pihl, RO; Etezadi, S; Lauze, C; Blier, P; Baker, GB; Benkelfat, C;
Indirizzi:
McGill Univ, Dept Psychiat, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 hiat, Montreal, PQ H3A 1A1, Canada McGill Univ, Dept Psychol, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 chol, Montreal, PQ H3A 1A1, Canada McGill Univ, Sch Dietet & Human Nutr, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Nutr, Montreal, PQ H3A 1A1, Canada Univ Alberta, Dept Psychiat, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada rta, Dept Psychiat, Edmonton, AB, Canada
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 22, anno: 2000,
pagine: 52 - 63
SICI:
0893-133X(200001)22:1<52:EOMOAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; GAMMA-AMINOBUTYRIC-ACID; METHYL-PARA-TYROSINE; TRYPTOPHAN DEPLETION; CATECHOLAMINE DEPLETION; AFFECTIVE-DISORDERS; DOPAMINE SYNTHESIS; PANIC DISORDER; NORMAL MALES; AMINO-ACIDS;
Keywords:
norepinephrine; dopamine; serotonin; tryptophan; depression; anxiety; stress; cardiovascular activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Young, SN McGill Univ, Dept Psychiat, 1033 Pine Ave W, Montreal, PQ H3A 1A1, Canada McGill Univ 1033 Pine Ave W Montreal PQ Canada H3A 1A1 1, Canada
Citazione:
M. Leyton et al., "Effects on mood of acute phenylalanine/tyrosine depletion in healthy women", NEUROPSYCH, 22(1), 2000, pp. 52-63

Abstract

Catecholamines have been implicated in the etiology and pathophysiology ofmood and anxiety disorders. In the present study, we investigated the effects of experimentally reducing catecholamine neurotransmission by means of acute phenylalanine/tyrosine depletion (APTD). healthy female volunteers ingested: (1) a nutritionally balanced amino acid (AA) mixture (n = 14); (2) a mixture deficient in the serotonin precursor, tryptophan (n = 15); or (3)one deficient in the catecholamine precursors, phenylalanine and tyrosine (n = 12). Mood was measured at three times: at baseline and both immediately before and after an aversive psychological challenge (public speaking andmental arithmetic) conducted 5 hours after AA mixture ingestion. Acute tryptophan depletion (ATD) lowered mood and energy and increased irritability scores. These effects were statistically significant only after the psychological challenge. The effect of APTD on mood was similar to that of ATD. APTD did not attenuate the anxiety caused by the psychological challenge. These findings suggest that, in healthy women, reduced serotonin and/or catecholamine neurotransmission increases vulnerability to lowered mood, especially following exposure to aversive psychological events. [Neuropsychopharmacology 22;52-63, 2000] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 29/03/20 alle ore 16:20:07