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Titolo:
Instrumentally detected changes in motor functioning in patients with low levels of antipsychotic dopamine D-2 blockade
Autore:
Fitzgerald, PB; Kapur, S; Caligiuri, MP; Jones, C; Silvestri, S; Remington, G; Zipursky, RB;
Indirizzi:
Dandenong Area Mental Hlth Serv, Dandenong Psychiat Res Unit, Dandenong, Vic 3175, Australia Dandenong Area Mental Hlth Serv Dandenong Vic Australia3175 5, Australia Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Schizophrenia & Continuing Care Program, Toronto, ON, Canada Univ Toronto Toronto ON Canada tinuing Care Program, Toronto, ON, Canada Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, PET Ctr, Toronto, ON, Canada Univ Toronto Toronto ON Canada Mental Hlth, PET Ctr, Toronto, ON, Canada Univ Toronto, Baycrest Ctr, Rotman Res Inst, Toronto, ON, Canada Univ Toronto Toronto ON Canada Ctr, Rotman Res Inst, Toronto, ON, Canada Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA UnivCalif San Diego San Diego CA USA 92103 hiat, San Diego, CA 92103 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 22, anno: 2000,
pagine: 19 - 26
SICI:
0893-133X(200001)22:1<19:IDCIMF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NAIVE SCHIZOPHRENIC-PATIENTS; D2-DOPAMINE RECEPTOR OCCUPANCY; POSITRON EMISSION TOMOGRAPHY; PARKINSONS-DISEASE; BRAIN DOPAMINE; PET; ASYMMETRY; INDIVIDUALS; RIGIDITY;
Keywords:
Parkinsonism; antipsychotic medication; positron emission tomography; PET; D-2 occupancy; motor dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Fitzgerald, PB Dandenong Area Mental Hlth Serv, Dandenong Psychiat Res Unit, David St, Dandenong, Vic 3175, Australia Dandenong Area Mental Hlth ServDavid St Dandenong Vic Australia 3175
Citazione:
P.B. Fitzgerald et al., "Instrumentally detected changes in motor functioning in patients with low levels of antipsychotic dopamine D-2 blockade", NEUROPSYCH, 22(1), 2000, pp. 19-26

Abstract

Extrapyramidal side-effects (EPSE) of antipsychotic medication are relatedto the occupancy of dopamine D-2 receptors and there appears to be a threshold of D-2 occupancy below which clinically EPSE are unlikely to occur. Itis unclear whether there ar motor changes produced by 'subthreshold' levels of D-2 occupancy that are not detectable by clinical examination. This study was designed to investigate whether a number of electromechanical instrumental techniques could detect 'subthreshold' motor changes and whether these changes correlate with dopamine D-2 occupancy as measured by [C-11]-raclopride PET scan. Twenty medication naive patients were studied before nd during treatment with low dose haloperidol. Instrumental techniques detectedan asymmetrical worsening in motor function with drug treatment despite the failure of the group to experience significant EPSE. These changes did not correlate with D2 occupancy and measurements of rigidity, tremor, and bradykinesia did not closely inter-correlate. [Neuropsychopharmacology 22:19-26, 2000] (C) 1999 American College of Neuropsychopharmacology. Published byElsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:35:31