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Titolo:
A deletion on Chromosome 4 cosegregates with the whirler deafness mutation: exclusion of Orm1 as a candidate
Autore:
Paige, AJW; Kiernan, BW; Varela, A; Rogers, MJC; Hughes, D; Steel, KP; Brown, SDM;
Indirizzi:
MRC, Mammalian Genet Unit, Didcot OX11 0RD, Oxon, England MRC Didcot OxonEngland OX11 0RD net Unit, Didcot OX11 0RD, Oxon, England MRC, Mouse Genome Ctr, Didcot OX11 0RD, Oxon, England MRC Didcot Oxon England OX11 0RD nome Ctr, Didcot OX11 0RD, Oxon, England MRC, Inst Hearing Res, Nottingham NG7 2RD, England MRC Nottingham England NG7 2RD Hearing Res, Nottingham NG7 2RD, England
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 1, volume: 11, anno: 2000,
pagine: 51 - 57
SICI:
0938-8990(200001)11:1<51:ADOC4C>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-1-ACID GLYCOPROTEIN GENES; ALPHA1-ACID GLYCOPROTEIN; REGULATORY REGION; LINKAGE ANALYSIS; BASIC DRUGS; MOUSE; BINDING; EXPRESSION; IDENTIFICATION; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Paige, AJW Western Gen Hosp, Imperial Canc Res Fund, MOU, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH42XU cotland
Citazione:
A.J.W. Paige et al., "A deletion on Chromosome 4 cosegregates with the whirler deafness mutation: exclusion of Orm1 as a candidate", MAMM GENOME, 11(1), 2000, pp. 51-57

Abstract

Whirler (wi) mice display profound deafness and a head-tossing and circling phenotype, showing an autosomal recessive mode of inheritance. The wi mutation has been shown to map close to the Orm gene cluster on mouse Chromosome (Chr) 4. We have, therefore, investigated the Orm loci as candidates forthe whirler gene. Detailed mapping and analysis of the Orm gene cluster inboth normal and whirler mice indicates the presence of a <48-kb deletion in whirler mice that disrupts the Orm1 locus. The Orm1 locus is also deletedin the CE/J mouse strain, and we discuss the candidature of Orm1 for the whirler gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:06:17