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Titolo:
Hypoperfusion of inferior frontal brain regions in abstinent alcoholics: Apilot SPECT study
Autore:
Gansler, DA; Harris, GJ; Oscar-Berman, M; Streeter, C; Lewis, RF; Ahmed, I; Achong, D;
Indirizzi:
Dept Vet Affairs New England Healthcare Syst, Psychol Serv, Boston, MA USADept Vet Affairs New England Healthcare Syst Boston MA USA oston, MA USA Tufts Univ, New England Med Ctr, Sch Med, Dept Psychiat, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 h Med, Dept Psychiat, Boston, MA 02111 USA
Titolo Testata:
JOURNAL OF STUDIES ON ALCOHOL
fascicolo: 1, volume: 61, anno: 2000,
pagine: 32 - 37
SICI:
0096-882X(200001)61:1<32:HOIFBR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; ATROPHY; HYPOMETABOLISM; REVERSIBILITY; METABOLISM; PERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Oscar-Berman, M Dept Vet Affairs New England Healthcare Syst, Psychol Res Serv 151A, 150 SHuntington Ave, Boston, MA 02130 USA Dept Vet Affairs New England Healthcare Syst 150 S Huntington Ave Boston MA USA 02130
Citazione:
D.A. Gansler et al., "Hypoperfusion of inferior frontal brain regions in abstinent alcoholics: Apilot SPECT study", J STUD ALC, 61(1), 2000, pp. 32-37

Abstract

Objective: This pilot study evaluated hypotheses concerning the relationship between cerebral hypoperfusion and residual deficits in the functioning of frontal brain systems in abstinent long-term alcoholics. Method: The participants (N = 22) were 10 healthy, abstinent alcoholics (9 men) and 12 age-equivalent nonalcoholic controls (10 men). Cerebral blood flow was observed through the use of regionally specific computer-derived quantitative analysis of single photon emission computed tomography (SPECT) perfusion images. Measures of alcohol use, abstinence and neuro-psychological functioning were also obtained to relate to SPECT findings. Results: A positive relationship was observed between per fusion levels in the left inferior frontal brain region and years of sobriety. Alcoholics with less than 4 years of sobriety had significantly reduced left inferior frontal perfusion compared with both nonalcoholic controls and alcoholics having longer periods of sobriety. Conclusions: The findings support the hypothesis that frontal brain abnormalities in alcoholics may subside with extended abstinence.

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Documento generato il 02/04/20 alle ore 00:15:47