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Titolo:
Capsaicin restores gubernacular contractility in TS rats
Autore:
Hrabovszky, Z; Hutson, JM;
Indirizzi:
Royal Childrens Hosp, Res Inst, F Douglas Stephens Surg Res Lab, Melbourne, Vic, Australia Royal Childrens Hosp Melbourne Vic Australia , Melbourne, Vic, Australia
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 12, volume: 34, anno: 1999,
pagine: 1769 - 1772
SICI:
0022-3468(199912)34:12<1769:CRGCIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; GENITOFEMORAL NERVE; TESTICULAR DESCENT; CREMASTER NUCLEUS; SPINAL NUCLEUS; CRYPTORCHIDISM; FEMINIZATION; DENERVATION; TERMINALS; RECEPTORS;
Keywords:
calcitonin gene-related peptide (CGRP); genitofemoral nerve; rat; cryptorchidism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hutson, JM Royal Childrens Hosp, Flemington Rd, Parkville, Vic 3052, Australia Royal Childrens Hosp Flemington Rd Parkville Vic Australia 3052
Citazione:
Z. Hrabovszky e J.M. Hutson, "Capsaicin restores gubernacular contractility in TS rats", J PED SURG, 34(12), 1999, pp. 1769-1772

Abstract

Background/Purpose: Calcitonin gene-related peptide (CGRP) may stimulate gubernacular migration during testicular descent by release from the genitofemoral nerve (GFN). The origin of CGRP within the nerve, however, is controversial. This study examines whether sensory nerve destruction alters gubernacular contractility in vitro in Sprague-Dawley (SD) and congenitally cryptochid (TS) rats. Methods: Part 1: Twenty-four SD and 16 TS rats (day 0) had either both GFNs transected or sham operation. Gubernacula were removed on day 2 and cultured with or without CGRP (714 nmol/L). Contractility was recorded by video. Part 2: Twenty-two SD and 17 TS rats (day 0) were injected with either capsaicin or vehicle. Gubernacula were removed (day 2) and cultured as above. Results: Part 1: In sham-operated SD rats gubernacular contracility increased from 8% to 83% with added CGRP. After GFN transection contractility wasnot affected by CGRP (21% without and 86% with CGRP; not significant). TS rat gubernacula had no endogenous contractions, but after GFN transection, the contractile response to CGRP increased from 6% to 44% (P = .04). Part 2: In vehicle-treated SD rats, rhythmic contractions increased from 10% to 86% with CGRP which was unchanged by capsaicin treatment (82%; not significant). In vehicle-treated TS rats, gubernacular contractions were 6% after CGRP After capsaicin pretreatment, contractions increased to 59% with CGRP (P= .002). Conclusions: Results of this study show that chemical destruction of sensory nerves restores gubernacular contractility in mutant cryptorchid TS rats. Release of CGRP appears to occur through sensory nerves. J Pediatr Surg 34:1769-1772. Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:42:32