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Titolo:
Functional inactivation of the amygdala before but not after auditory fearconditioning prevents memory formation
Autore:
Wilensky, AE; Schafe, GE; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, New York, NY 10003 USA NYU New York NY USA 10003 Keck Fdn Lab Neurobiol, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 24, volume: 19, anno: 1999,
pagine: E1 - E5
SICI:
0270-6474(199912)19:24<E1:FIOTAB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORY AVOIDANCE; BASOLATERAL AMYGDALA; ENTORHINAL CORTEX; PARIETAL CORTEX; HIPPOCAMPUS; LESIONS; CONSOLIDATION; RETENTION; RATS; INVOLVEMENT;
Keywords:
muscimol; learning; memory consolidation; amygdala; auditory fear conditioning; GABA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: LeDoux, JE NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, 4 Washington Pl,Room 809, New York, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 NY 10003 USA
Citazione:
A.E. Wilensky et al., "Functional inactivation of the amygdala before but not after auditory fearconditioning prevents memory formation", J NEUROSC, 19(24), 1999, pp. E1-E5

Abstract

Two competing theories predict different effects on memory consolidation when the amygdala is inactivated after fear conditioning. One theory, based on studies using inhibitory avoidance training, proposes that the amygdala modulates the strength of fear learning, and post-training amygdala manipulations interfere with memory consolidation. The other, based on studies using Pavlovian fear conditioning, hypothesizes that fear learning occurs in the amygdala, and post-training manipulations after acquisition will not affect memory consolidation. We infused the GABA(A) agonist muscimol (4.4 nmol/side) or vehicle into lateral and basal amygdala (LBA) of rats either before or immediately after tone-foot shock Pavlovian fear conditioning. Pre-training infusions eliminated acquisition, whereas post-training infusions had no effect. These findings indicate that synaptic activity in LBA is necessary during learning, but that amygdala inactivation directly after training does not affect memory consolidation. Results suggest that essential aspects of plasticity underlying auditory fear conditioning take place within LBA during learning.

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Documento generato il 25/09/20 alle ore 00:02:51