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Titolo:
Regulation of terminal Schwann cell number at the adult neuromuscular junction
Autore:
Lubischer, JL; Bebinger, DM;
Indirizzi:
Univ Texas, Sch Biol Sci, Inst Neurosci, Neurobiol Sect, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 osci, Neurobiol Sect, Austin, TX 78712 USA Univ Texas, Inst Mol & Cellular Biol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Mol & Cellular Biol, Austin, TX 78712 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 24, volume: 19, anno: 1999,
pagine: C1 - C5
SICI:
0270-6474(199912)19:24<C1:ROTSCN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEVATOR ANI MUSCLE; ANDROGEN RECEPTOR; STRIATED-MUSCLE; NEUREGULIN; MODULATION; CALCIUM; SIZE;
Keywords:
NMJ; SNB; motoneuron; steroid hormone; synaptic plasticity; perisynaptic Schwann cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lubischer, JL Univ Texas, Sch Biol Sci, Inst Neurosci, Neurobiol Sect, 24th & Speedway,140 Patterson Lab Bldg, Austin, TX 78712 USA Univ Texas 24th &Speedway,140 Patterson Lab Bldg Austin TX USA 78712
Citazione:
J.L. Lubischer e D.M. Bebinger, "Regulation of terminal Schwann cell number at the adult neuromuscular junction", J NEUROSC, 19(24), 1999, pp. C1-C5

Abstract

Terminal Schwann cells (TSCs), neuroglia that cover motoneuron terminals, play a role in regulating the structure and function of the neuromuscular junction. In rats, the number of TSCs at each junction increases rapidly in early postnatal life and more slowly in young adults. It is possible that TSC number increases to match increasing endplate area. Alternatively, the increase in TSC number may reflect a developmental process independent of endplate size or terminal function. To experimentally test the relationship between endplate size and TSC number, we manipulated endplate area in an androgen-sensitive muscle of the rat, the levator ani (LA), by castration and by androgen replacement. We found that TSC number not only increased as endplates enlarged but also decreased when endplates shrank. Ninety days aftercastration, TSC number decreased by similar to 20% (one cell per junction)as endplate size decreased by 30%. These effects were reversed by testosterone. Testosterone levels did not affect TSC number in the extensor digitorum longus (EDL) muscle, where endplate area was unaffected by castration ortestosterone treatment. TSC number was, however, significantly correlated with endplate area in both LA and EDL muscles. Furthermore, the relationship between endplate size and TSC number, as defined by the slope of the regression line, was the same in LA and EDL muscles, indicating that this relationship is not a unique feature of the LA muscle. These data suggest that TSC number is a dynamic property of the neuromuscular synapse that is actively regulated throughout life.

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Documento generato il 16/07/20 alle ore 15:17:20