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Titolo:
NMDA receptor antagonists acting at the glycine(B) site in rat models for antipsychotic-like activity
Autore:
Karcz-Kubicha, M; Wedzony, K; Zajaczkowski, W; Danysz, W;
Indirizzi:
Merz & Co, Dept Pharmacol Res, D-60318 Frankfurt, Germany Merz & Co Frankfurt Germany D-60318 acol Res, D-60318 Frankfurt, Germany Inst Pharmacol PAN, Krakow, Poland Inst Pharmacol PAN Krakow PolandInst Pharmacol PAN, Krakow, Poland
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 11-12, volume: 106, anno: 1999,
pagine: 1189 - 1204
SICI:
0300-9564(1999)106:11-12<1189:NRAAAT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; MESOLIMBIC DOPAMINE SYSTEM; PREPULSE INHIBITION; SCHIZOPHRENIC-PATIENTS; GLUTAMATE ANTAGONISTS; STARTLE RESPONSE; INDUCED DEFICITS; D-CYCLOSERINE; PHENCYCLIDINE; L-701,324;
Keywords:
amphetamine; phencyclidine; NMDA antagonists; prepulse inhibition; antipsychotics; glycine(B) antagonists; L-701,324; MRZ 2/576;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Danysz, W Merz & Co, Dept Pharmacol Res, Eckenheimer Landstr 100-104, D-60318 Frankfurt, Germany Merz & Co Eckenheimer Landstr 100-104 Frankfurt Germany D-60318
Citazione:
M. Karcz-Kubicha et al., "NMDA receptor antagonists acting at the glycine(B) site in rat models for antipsychotic-like activity", J NEURAL TR, 106(11-12), 1999, pp. 1189-1204

Abstract

Several partial agonist and full antagonists acting at the glycine site ofthe NMDA receptors were tested for potential antipsychotic-like propertiesin rats. As models, amphetamine- and phencyclidine (PCP)-induced locomotoractivation in the open field and PCP-induced impairment of prepulse inhibition of the acoustic startle response were employed. In the open field test, partial agonists, D-cycloserine failed to show any effect, aminocyclopropane carboxylic acid (ACPC) enhanced the action of PCP (but not that of amphetamine) and R(+)HA-966 attenuated the locomotor activation produced by both amphetamine and PCP. Both full glycine, antagonists, L-701,324 and MRZ 2/576 attenuated the action of amphetamine and PCP but at the doses that alsoproduce transient behavioural inhibition in naive animals. A competitive NMDA receptor antagonist CGP 39551 was ineffective. In the prepulse inhibition test neither L-701,324 nor MRZ 2/576 changed sensorimotor gating in naive animals nor attenuated the disrupting effects of PCP. The present data donot support antipsychotic profile of glycine, full antagonists. However, psychotomimetic potential of glycine, antagonists seems to be low.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:25:04