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Titolo:
FAMILY HISTORY OF PROSTATE-CANCER IN PATIENTS WITH LOCALIZED PROSTATE-CANCER - AN INDEPENDENT PREDICTOR OF TREATMENT OUTCOME
Autore:
KUPELIAN PA; KUPELIAN VA; WITTE JS; MACKLIS R; KLEIN EA;
Indirizzi:
CLEVELAND CLIN FDN,DEPT RADIAT ONCOL,DESK T28 CLEVELAND OH 44195 CLEVELAND CLIN FDN,DEPT UROL CLEVELAND OH 44195 CASE WESTERN RESERVE UNIV,DEPT EPIDEMIOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT BIOSTAT CLEVELAND OH 44106
Titolo Testata:
Journal of clinical oncology
fascicolo: 4, volume: 15, anno: 1997,
pagine: 1478 - 1480
SICI:
0732-183X(1997)15:4<1478:FHOPIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADICAL PROSTATECTOMY; RADIATION-THERAPY; ANTIGEN; FEATURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Kupelian et al., "FAMILY HISTORY OF PROSTATE-CANCER IN PATIENTS WITH LOCALIZED PROSTATE-CANCER - AN INDEPENDENT PREDICTOR OF TREATMENT OUTCOME", Journal of clinical oncology, 15(4), 1997, pp. 1478-1480

Abstract

Purpose: To determine if familial prostate cancer patients have a less favorable prognosis than patients with sporadic prostate cancer after treatment for localized disease with either radiotherapy (RT) or radical prostatectomy (RP). Patients and Methods: One thousand thirty-eight patients treated with either RT (n = 583) or RP (n = 455) were included in this analysis, These patients were noted as having a positive family history if they confirmed the diagnosis of prostate cancer in afirst-degree relative, The outcome oi: interest was biochemical relapse-free survival (bRFS). We used proportional hazards to analyze the effect of the presence of family history and other potential confounding variables (ie, age, treatment modality, stage, biopsy Gleason sum [GS], and initial prostate-specific antigen [iPSA] levels) on treatment outcome. Results: Eleven percent of all patients had a positive familyhistory, The 5-year bRFS rates for patients with negative and positive family histories were 52% and 29%, respectively (P < .001). The potential confounders with bRFS rates were iPSA levels, biopsy GS, and clinical tumor stage; treatment modality and age did not appear to be associated with outcome. After adjusting for potential confounders, family history of prostate cancer remained strongly associated with biochemical failure. Conclusion: This is the first study to demonstrate that the presence of a family history of prostate cancer correlates with treatment outcome in a large unselected series of patients. Our findingssuggest that familial prostate cancer may have a more aggressive course than nonfamilial prostate cancer, and that clinical and/or pathologic parameters may not adequately predict this course. (C) 1997 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:53:19