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Titolo:
The Arthus reaction in rodents: Species-specific requirement of complement
Autore:
Szalai, AJ; Digerness, SB; Agrawal, A; Kearney, JF; Bucy, RP; Niwas, S; Kilpatrick, JM; Babu, YS; Volanakis, JE;
Indirizzi:
Univ Alabama, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294USA Univ Alabama Birmingham AL USA 35294 & Rheumatol, Birmingham, AL 35294USA Univ Alabama, Dept Surg, Birmingham, AL 35294 USA Univ Alabama BirminghamAL USA 35294 Dept Surg, Birmingham, AL 35294 USA Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Microbiol, Birmingham, AL 35294 USA Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Pathol, Birmingham, AL 35294 USA BioCryst Pharmaceut, Birmingham, AL 35244 USA BioCryst Pharmaceut Birmingham AL USA 35244 eut, Birmingham, AL 35244 USA Biomed Sci Res Ctr A Fleming, Vari, Greece Biomed Sci Res Ctr A Fleming Vari Greece es Ctr A Fleming, Vari, Greece
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 1, volume: 164, anno: 2000,
pagine: 463 - 468
SICI:
0022-1767(20000101)164:1<463:TARIRS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENT MICE; PROTEIN-B; INFLAMMATION; INHIBITION; PATHWAY; PLASMA; DRUGS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Szalai, AJ Univ Alabama, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294USA Univ Alabama Birmingham AL USA 35294 , Birmingham, AL 35294USA
Citazione:
A.J. Szalai et al., "The Arthus reaction in rodents: Species-specific requirement of complement", J IMMUNOL, 164(1), 2000, pp. 463-468

Abstract

We induced reverse passive Arthus (RPA) reactions in the skin of rodents and found that the contribution of complement to immune complex-mediated inflammation is species specific. Complement was found to be necessary in ratsand guinea pigs but not in C57BL/6J mice. In rats, within 4 h after initiation of an RPA reaction, serum alternative pathway hemolytic titers decreased significantly below basal levels, whereas classical pathway titers were unchanged. Thus the dermal reaction proceeds coincident with systemic activation of complement. The serine protease inhibitor BCX 1470, which blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. These data support the proposal that complement-mediated processes are of major importance in the Arthus reaction in rats and guinea pigs, and suggest that BCX 1470 will be useful as an anti-inflammatory agent in diseases where complement activation is known to be detrimental.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:18:09