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Titolo:
Processing of biodegradable polymer composites as a drug delivery system in vitro
Autore:
Liu, SJ; Tsai, CH; Lin, SS; Ueng, SWN;
Indirizzi:
Chang Gung Univ, Dept Mech Engn, Polymer Rheol & Proc Lab, Tao Yuan 333, Taiwan Chang Gung Univ Tao Yuan Taiwan 333 eol & Proc Lab, Tao Yuan 333, Taiwan Chang Gung Mem Hosp, Dept Orthoped Surg, Tao Yuan, Taiwan Chang Gung Mem Hosp Tao Yuan Taiwan ept Orthoped Surg, Tao Yuan, Taiwan
Titolo Testata:
INTERNATIONAL POLYMER PROCESSING
fascicolo: 4, volume: 14, anno: 1999,
pagine: 322 - 325
SICI:
0930-777X(199912)14:4<322:POBPCA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBIOTICS; DEVICES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Liu, SJ Chang Gung Univ, Dept Mech Engn, Polymer Rheol & Proc Lab, 259 WenHwa 1stRd, Tao Yuan 333, Taiwan Chang Gung Univ 259 Wen Hwa 1st Rd Tao Yuan Taiwan 333 33, Taiwan
Citazione:
S.J. Liu et al., "Processing of biodegradable polymer composites as a drug delivery system in vitro", INT POLYM P, 14(4), 1999, pp. 322-325

Abstract

This report explores the alternative of processing biodegradable polymer-antibiotic composites as a long-term drug release. Polymer-antibiotic composite bean's Mere manufactured by a compression-sintering technique. An elution method was employed to characterize the release rate of antibiotic over a 35-day period at 37 degrees C. Biodegradable polymer composites released high concentrations of antibiotic (well above the breakpoint sensitivity concentration) in vitro for the period of time needed to treat bone infection; i.e. 4 to 6 weeks. By changing the processing variables, one is able to control the release rate of the beads. This provides advantages of meeting the specific antibiotic requirement for patients with various surgical infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:33:00