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Titolo:
Elevated GM-CSF levels in tumor bearing mice upregulate IL-6 production byB cells via a mechanism independent of TNF-alpha
Autore:
Charyulu, VI; Lopez, DM;
Indirizzi:
Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33101 USA Univ Miami Miami FL USA 33101 pt Microbiol & Immunol, Miami, FL 33101 USA Univ Miami, Sch Med, Sylvester Canc Ctr, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 ed, Sylvester Canc Ctr, Miami, FL 33136 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 16, anno: 2000,
pagine: 161 - 167
SICI:
1019-6439(200001)16:1<161:EGLITB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; MAMMARY-TUMOR; HUMAN-FIBROBLASTS; MESSENGER-RNA; LYMPHOCYTE-B; ACUTE PHASE; INTERLEUKIN-6; INDUCTION; MACROPHAGES; EXPRESSION;
Keywords:
IL-6; granulocyte-macrophage colony stimulating factor; TNF-alpha; tumor bearing mice; B-cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lopez, DM Univ Miami, Sch Med, Dept Microbiol & Immunol, POB 016960 R-138,Miami, FL33101 USA Univ Miami POB 016960 R-138 Miami FL USA 33101 iami, FL33101 USA
Citazione:
V.I. Charyulu e D.M. Lopez, "Elevated GM-CSF levels in tumor bearing mice upregulate IL-6 production byB cells via a mechanism independent of TNF-alpha", INT J ONCOL, 16(1), 2000, pp. 161-167

Abstract

During mammary tumorigenesis a profound dysregulation of cytokine production by various lymphoreticular cells has been documented. B lymphocytes fromtumor bearers have an increased production of tumor necrosis factor a (TNF-alpha). We now report that these lymphocytes have elevated levels of interleukin 6 (IL-6) at the transcriptional and translational levels, that are reflected systemically. The mammary tumor used in our study constitutively produces several factors including granulocyte-macrophage colony stimulatingfactor (GM-CSF), prostaglandin E-2 (PGE(2)) and phosphatidyl serine (PS), which directly or indirectly can affect the cells of the immune system. In vitro addition of GM-CSF resulted in a dramatic increase in IL-6 levels from B cells from normal mice. This effect does not appear to be due to elevated levels of TNF-alpha, known to upregulate IL-6 Rather, GM-CSF activates IL-6 production independently of TNF-alpha as demonstrated by neutralizationstudies using anti-TNF-alpha antibodies. Furthermore, the effect exerted by GM-CSF on IL-6 production by B lymphocytes appears to be direct since pretreatment of cultures with anti-GM-CSF completely abrogated the elevated production of IL-6. The elevated levels of IL-6 and TNF-alpha in tumor bearers may contribute to the cachectic state observed in tumor bearing mice.

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Documento generato il 11/07/20 alle ore 16:49:51