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Titolo:
Estrogen enhances induction of cytochrome P-4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in lives of female Long-Evans rats
Autore:
Sarkar, S; Jana, NR; Yonemoto, J; Tohyama, C; Sone, H;
Indirizzi:
Natl Inst Environm Studies, Div Reg Environm, Chem Exposure & Hlth EffectsRes Team, Ibaraki, Osaka 3050053, Japan Natl Inst Environm Studies IbarakiOsaka Japan 3050053 aka 3050053, Japan Natl Inst Environm Studies, Environm Hlth Sci Div, Ibaraki, Osaka 3050053,Japan Natl Inst Environm Studies Ibaraki Osaka Japan 3050053 saka 3050053,Japan JST, CREST, Kawaguchi, Saitama 3320012, Japan JST Kawaguchi Saitama Japan3320012 ST, Kawaguchi, Saitama 3320012, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 16, anno: 2000,
pagine: 141 - 147
SICI:
1019-6439(200001)16:1<141:EEIOCP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER CELLS; NUCLEAR TRANSLOCATOR; TRANSIENT EXPRESSION; AH-RECEPTOR; CYP1A1; GENE;
Keywords:
2,3,7,8-tetrachlorodibenzo-p-dioxin; CYP1A1; estrogen; estrogen receptor; arylhydrocarbon receptor; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sone, H Natl Inst Environm Studies, Div Reg Environm, Chem Exposure & HlthEffectsRes Team, 16-2 Onogawa, Ibaraki, Osaka 3050053, Japan Natl Inst Environm Studies 16-2 Onogawa Ibaraki Osaka Japan 3050053
Citazione:
S. Sarkar et al., "Estrogen enhances induction of cytochrome P-4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in lives of female Long-Evans rats", INT J ONCOL, 16(1), 2000, pp. 141-147

Abstract

A human carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces liver tumors in female rats. In this study, we examined the effects of estrogen on an arylhy-drocarbon receptor (AhR)-responsible protein, CYP1A1 expression induced by TCDD in female rat livers. The induction of CYP1A1 by a doseof 300 ng TCDD/kg and its resultant enzymatic activity were significantly enhanced by 5 mu g 17 beta-estradiol/kg body weight treatment to both intact and ovariectomized rats. Immunoblot analysis showed a increase in nuclearAhR due to estrogen, TCDD or both, suggesting that estrogen is involved inthe activation of CYP1A1 gene after the formation of AhR-TCDD complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 04:03:39