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Titolo:
Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester
Autore:
Ladriere, L; Bjorkling, F; Malaisse, WJ;
Indirizzi:
Free Univ Brussels, Expt Med Lab, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 Lab, B-1070 Brussels, Belgium Leo Pharmaceut Prod, DK-2750 Ballerup, Denmark Leo Pharmaceut Prod Ballerup Denmark DK-2750 , DK-2750 Ballerup, Denmark
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 5, anno: 2000,
pagine: 63 - 65
SICI:
1107-3756(200001)5:1<63:SOIRIH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERGLYCEMIC RATS; ANESTHETIZED RATS; GLIBENCLAMIDE; POTENTIATION; ENHANCEMENT; GLIMEPIRIDE; PANCREAS;
Keywords:
Goto-Kakizaki rats; nateglinide; succinic acid ester;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Malaisse, WJ Free Univ Brussels, Expt Med Lab, 808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels 808 Route Lennik Brussels Belgium B-1070
Citazione:
L. Ladriere et al., "Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester", INT J MOL M, 5(1), 2000, pp. 63-65

Abstract

Hereditarily diabetic Goto-Kakizaki rats were infused for 5 min with saline, containing as required nateglinide or mixed molecules (HD154 and HD166) with both a nateglinide moiety and a succinic acid eater moiety. The dose of these agents given intravenously amounted to 5.0 nmol/g body weight in all cases. All agents provoked a comparable early increase in plasma insulin concentration. However, HD154 and HD166, but not nateglinide itself, also caused a secondary rise in plasma insulin concentration 30 min after their infusion. It is proposed that mixed molecules formed of both a hypoglycemic sulfonylurea or meglitinide analog and a succinic acid ester may be better able than the antidiabetic agents themselves to evoke a sustained stimulation of insulin release in non-insulin-dependent diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:25:55